- ¥1908
- ebioscience
- 11-0333-82
- 2025年07月11日
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- 详细信息
- 技术资料
- 抗体英文名：
Anti-Mouse Siglec H FITC
- 规格：
100ug
The monoclonal antibody eBio440c recognizes Siglec-H, a protein exclusively found on
pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naïve mouse.
Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond
to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have
been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM
domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a
cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction.
The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion
in response to CpG).
It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs
compared to C57BL/6.
pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naïve mouse.
Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond
to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have
been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM
domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a
cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction.
The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion
in response to CpG).
It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs
compared to C57BL/6.
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Anti-Mouse Siglec H FITC
¥1908
