免疫病理miRNA PCR 芯片Immunopatholog

Human Immunopathology miRNA PCR Array: MIHS-104Z
The Human Immunopathology miScript miRNA PCR Array profiles the expression of 84 miRNAs differentially expressed during normal and pathological responses by the immune system. This array provides immunology researchers with a convenient way to quickly analyze the miRNAs most relevant to the function of lymphocytes and other immune cells. The miRNAs have been carefully selected based on results published in peer-reviewed journals that suggest a correlation with inflammation, leukemia, lymphoma, autoimmune disorders, or other immune responses. Other miRNAs included on the array have been shown to functionally target specific transcripts encoding cytokines, other immunological regulatory proteins, and immune response signaling pathway components. The profiling results from this array can serve as a useful molecular marker for the study of normal and disease-associated immune responses. The results may also provide a deeper understanding of the molecular mechanisms regulating immunological gene expression by miRNA. A set of controls present on this array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green-based real-time PCR, the expression of a focused panel of miRNAs related to immunopathology can be easily and reliably analyzed with this miScript miRNA PCR Array. miScript miRNA PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention or treatment of a disease. 96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available.

Leukemia & Lymphoma:
Hodgkin's Lymphoma: miR-125b-5p, miR-126-3p, miR-128, miR-130a-3p, miR-132-3p, miR-134, miR-135a-5p, miR-135b-5p, miR-138-5p, miR-142-3p, miR-142-5p, miR-145-5p, miR-147a, miR-15b-5p, miR-181a-5p, miR-183-5p, miR-185-5p, miR-200a-3p, miR-205-5p, miR-20b-5p, miR-21-5p, miR-23b-3p, miR-26a-5p, miR-26b-5p, miR-27a-3p, miR-29b-3p, miR-302a-3p, miR-30c-5p, miR-31-5p, miR-325, miR-335-5p, miR-34a-5p, miR-9-5p.
Other: miR-15a-5p.
Primary Effusion Lymphoma: miR-103a-3p, miR-106a-5p, miR-142-3p, miR-148a-3p, miR-152, miR-16-5p, miR-182-5p, miR-186-5p, miR-191-5p, miR-194-5p, miR-19a-3p, miR-210, miR-23b-3p, miR-26a-5p, miR-29b-3p, miR-30e-5p, miR-34a-5p.
T-cell Leukemia: miR-106a-5p, miR-132-3p, miR-18b-5p, miR-19b-3p, miR-20b-5p, miR-363-3p.
Autoimmune Disorders:
Idiopathic Thrombocytopenic Purpura: miR-196a-5p, miR-214-3p, miR-298, miR-299-3p, miR-379-5p, miR-383, miR-409-3p.
Systemic Lupus Erythematosus: miR-142-3p, miR-184, miR-196a-5p, miR-21-5p, miR-298, miR-299-3p, miR-383, miR-409-3p.
Inflammatory Responses:
IL-1 Induced Inflammatory Response: let-7g-5p, miR-146a-5p, miR-195-5p, miR-26b-5p.
Inflammation Mediators: miR-155-5p, miR-203a.
Macrophage Inflammatory Response: miR-132-3p, miR-155-5p.
Vascular Inflammation: miR-126-3p, miR-155-5p, miR-21-5p.
Others: miR-125a-5p.
Innate Immune Response: miR-105-5p, miR-146a-5p, miR-19a-3p, miR-19b-3p.
Induced in Monocytes By LPS: let-7e-5p, miR-132-3p, miR-146a-5p, miR-155-5p, miR-187-3p, miR-9-5p, miR-99b-5p.
Immune Cells:
B Cell Differentiation: miR-150-5p.
Invariant Natural Killer Cell Development: miR-155-5p, miR-150-5p.
Lymphocytes: let-7e-5p, miR-125a-5p, miR-142-5p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-148a-3p, miR-195-5p, miR-206, miR-223-3p, miR-451a, miR-493-3p, miR-574-3p.
Monocytopoiesis: miR-106a-5p, miR-20a-5p.
Natural Regulatory T Cells: miR-103a-3p, miR-142-5p, miR-149-5p, miR-150-5p, miR-15b-5p, miR-16-5p, miR-191-5p, miR-19a-3p, miR-21-5p, miR-214-3p, miR-223-3p, miR-26a-5p, miR-27b-3p, miR-29c-3p, miR-30b-5p, miR-30c-5p, miR-30e-5p.
Th2 Cells: miR-126-3p.
Regulates Relevant Genes:
Cytokines: miR-98-5p.
Interferons & Receptors: miR-146a-5p, miR-223-3p.
Interleukins: miR-106a-5p, miR-146a-5p, miR-155-5p, miR-15a-5p, miR-181a-5p, miR-223-3p, miR-223-3p.
STAT3: miR-18a-5p, miR-19a-3p, miR-19b-3p, miR-20a-5p.
TNF Alpha: miR-125b-5p, miR-155-5p.
Signal Transduction:
IL6 / STAT3 Signaling: let-7a-5p, let-7c, let-7d-5p, miR-21-5p.
NFKB Signaling: miR-146a-5p, miR-155-5p.