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- 详细信息
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- 文献和实验
- 技术资料
- 服务名称：
PCR芯片
- 提供商：
SABio
| Product | Species | Technology | Cat. No. |
| Telomeres & Telomerase PCR Array | Human | Gene Expression | PAHS-010Z |
| Telomeres & Telomerase PCR Array | Mouse | Gene Expression | PAMM-010Z |
| Telomeres & Telomerase PCR Array | Rat | Gene Expression | PARN-010Z |
Telomere Maintenance: ACD, BLM, DCLRE1C, DKC1, ERCC1, ERCC4, HSPA1L, MRE11A, MYC, NBN (NBS1), PARP1 (ADPRT1), PIF1, POT1, PRKDC, PTGES3, RAD50, RFC1, RTEL1, SMG6, TEP1, TERF1, TERF2, TERF2IP, TERT, TINF2, TNKS (TIN1), TNKS2, XRCC5, XRCC6 (G22P1). Telomere-Associated Complexes: Shelterin: ACD, POT1, RAP1A, TERF1, TERF2, TINF2. Telomerase: DKC1, GAR1, NHP2, NOP10, TERT, WRAP53. SLX4: SLX4, ERCC1, ERCC4, EME1, MSH2, MSH3, MUS81, PLK1, TERF2, TERF2IP. Telomere Regulation: Regulation of Telomere Length: RTEL1, TEP1, TERF1, TERF2IP, TNKS (TIN1). Shelterin Complex Regulation: DCLRE1B, KRIT1, RASSF1, RAPGEF1, TPP1. Telomerase Regulation: ABL1, AKT1, ATP5C1, BCL2, EGF, IGF1, KRAS, MEN1, MYC, PAX8, PINX1, PPARG, PPP2R1A, PPP2R1B, PRKCA, PRKCB, RB1, SART1, SMAD3, SP1, SSB, TGFB1, TP53. Other Genes Associated with Telomeres: ATM, CDK2, CHEK1, CHEK2 (RAD53), HAT1, HNRNPA2B1, HNRNPD, HSP90AA1, NCL, OBFC1, PURA, RAD17, RIF1, SIRT2, SIRT6, TP53BP1, SUN1.
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文献和实验荧光定量 PCR不但能有效地检测到基因的突变，而且可以准确检测癌基因的表达量。目前用此方法进行过端粒酶hTERT基因、慢性粒细胞性白血病WT1基因、肿瘤 ER基因、前列腺癌PSM基因、肿瘤相关的病毒基因等多种基因的表达检测。
In Situ Analysis of Telomerase RNA Gene Expression as a Marker for Tumor Progression
), and the interaction of telomerase with other telomere associated proteins ( 10 , 15 – 20 ; see Fig. 1 ). The use of telomerase as a diagnostic marker and target for cancer therapy relies on the development of reliable assays and technologies to detect telomeres
Array CGH of Microdissected Fresh or Formalin Fixed DNA
Random Prime Amplification of DNA from small tumors (fresh or paraffin) We generally use 50 nanograms of fresh or paraffin microdissected Taqman-quantitated DNA (see microdissection protocol) for each array hybridization
