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- PR-1006P
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- 2025年07月09日
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- rabbit
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- 文献和实验
- 技术资料
- 适应物种：
,
- 应用范围：
,
- 库存：
大量
- 级别：
免疫亲和纯化
- 抗体英文名：
PRMT4(phospho S228)
- 是否单克隆：
0
- 供应商：
厚普生物
- 抗原来源：
human
- 保质期：
2年
- 宿主：
rabbit
- 保存条件：
4度
- 规格：
0.1ml
PRMT4 (phospho S228) Antibody
Catalog Number:PR-1006P
Background: Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor mediated signaling, and transcription. PRMT4, also known as CARM1, catalyses the mono- and asymmetric dimethylation of arginine residues in several proteins involved in DNA packaging, transcription regulation and mRNA stability. PRMT4 methylates R2, R17 and R26 of histone H3 and cooperates synergistically with p300/CBP and p160 coactivators to enhance transcriptional activation by nuclear receptors. PRMT4 also methylates several non-histone proteins, including transcriptional coactivators such as p300/CBP, splicing factors and RNA binding proteins. PRMT4 is also a co-activator of p53, facilitating p53-mediated transcription through the methylation of histones H3 and H4.
Description: Rabbit polyclonal to PRMT4(phospho S228)
Immunogen: A synthesized phosphopeptide derived from human PRMT4 around the phosphorylation site of serine 228 (V-K-SP-N-N).
Specificity: ·Reacts with Human, Mouse, Pig, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/500-1000. Predicted Mol wt: 63 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/200-500;
·ELISA: 1/500;
· Optimal working dilutions must be determined by the end user.
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文献和实验Optimized Protocol to Make Phospho-Specific Antibodies that Work
, not simply its level of expression. In this review, we will discuss both the design of the phosphopeptide immunogen and immunization. The affinity purification of the phospho-specific antibody as well as the methods most suitable for characterizing
Using Phospho‐Motif Antibodies to Determine Kinase Substrates
comprising both the phosphorylated residue and the surrounding residues that determine kinase specificity, with degenerate residues taking up the remaining positions. Currently, several categories of phospho?motif antibody are commercially available
Absorption Control in Immunohistochemistry Using Phospho-Peptides Immobilized on Magnetic Beads
neutralization of phospho-specific antibodies with phospho-peptides immobilized on magnetic beads. This technique allows for sequestration of antibody–peptide complex from the incubation solution, minimizing the risk of formation of unblocked antibodies capable
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