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- 文献和实验
- 技术资料
- 库存：
999
- 英文名：
TD-198946
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 供应商：
北京索莱宝科技有限公司
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 规格：
1mg/5mg/10mg
| 规格： | 1mg | 产品价格： | ¥888.00 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ¥1800.00 |
| 规格： | 10mg | 产品价格： | ¥2860.00 |
| CAS | 364762-86-7 |
| 英文名称 | TD-198946 |
| 分子式 | C27H22N4O3S |
| 分子量 | 482.55 |
| 规格 | 1mg ; 5mg ; 10mg |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥98% |
| 外观(性状) | White to light yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| 运输条件 | 冷藏运输 |
| SMILES | CN1C2=C(CCC3=C(SC(=C32)OC4=CC=C(C=C4)OCC5=NC6=CC=CC=C6C=C5)C(=O)N)C=N1 |
| InChIKey | QGAMAWMLTUNPAB-UHFFFAOYSA-N |
| InChI | InChI=1S/C27H22N4O3S/c1-31-24-17(14-29-31)7-13-21-23(24)27(35-25(21)26(28)32)34-20-11-9-19(10-12-20)33-15-18-8-6-16-4-2-3-5-22(16)30-18/h2-6，8-12，14H，7，13，15H2，1H3，(H2，28，32) |
| PubChem CID | 9826550 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | TD-198946是一种高效的软骨形成剂。 |
| 生物活性 | TD-198946， a thienoindazole derivative， is a potent chondrogenic agent.[1-4] |
| In Vitro | TD-198946 is a potent chondrogenic agent. TD-198946 strongly induces chondrogenic differentiation without promoting hypertrophy in cell and metatarsal organ cultures. TD-198946 induces stronger Col2a1 promoter activity than insulin in ATDC5 cells. In C3H10T1/2 cells， ATDC5 cells and primary mouse chondrocytes， TD-198946 dose-dependently stimulates endogenous expression of the chondrocyte markers Col2a1 and Acan， with maximum effects around 1-10 μM[1]. |
| In Vivo | When administered directly into the joint space， TD-198946 successfully prevents and repaires degeneration of the articular cartilage. TD-198946 exerts its effect through the regulation of Runx1 expression， which is downregulated in both mouse and human OA cartilage compared with normal tissue[1]. TD-198946 has disease-modifying effects on progressed osteoarthritis. TD-198946 may prevent the progression of osteoarthritis by acting on the remaining chondrocytes rather than repairing damaged cartilage， it may be most effective as a therapeutic during the early or middle stages of osteoarthritis， before the articular cartilage is fully eroded[2]. Cartilaginous cell-sheets are generated by culturing mouse and canine costal chondrocytes and human mesenchymal stem cells with TD-198946 on temperature-responsive dishes. The transplanted cell-sheets are then successfully used to promote the reconstruction of permanent cartilage， with no evidence of chondrocyte hypertrophy in the knee articular cartilage defects created in mice and canines[3]. |
| 动物实验 | Mice: Each of the prevention and repair models had two groups: (1) TD-198946-treated animals and (2) saline-treated animals. In all the mice tested the left knee joints underwent the operation and the right knee joints are sham-operated. Mice are re-anaesthetised and given a 10 μL intra-articular injection of TD-198946 or saline immediately after surgery (prevention model) or 4 weeks following surgery (repair model) every 5 days for 8 or 4 weeks， respectively[1]. |
| 数据来源文献 | [1]. Yano F， et al. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis. 2013 May;72(5):748-53. [2]. Yano F， et al. Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis. 2014 Nov;73(11):2062-4. [3]. Yano F， et al. Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials. 2013 Jul;34(22):5581-7. [4]. Kobayashi M， Chijimatsu R， Hart DA， et al. Evidence that TD-198946 enhances the chondrogenic potential of human synovium-derived stem cells through the NOTCH3 signaling pathway. J Tissue Eng Regen Med. 2021;15(2):103-115. |
| 单位 | 瓶 |
| 表格1 | |*|1mg|5mg|10mg|$$|1mM|2.0723mL|10.3616mL|20.7232mL|$$|5mM|0.4145mL|2.0723mL|4.1446mL|$$|10mM|0.2072mL|1.0362mL|2.0723mL| |
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文献和实验干货 | CUT and Tag 让 ChIP-Seq更简单高效！
&Tag 技术的实验流程简单，可一步实现 DNA 的片段化和接头连接，仅需 9h 即可实现从细胞到二代测序文库的转化。 实验流程主要包括：①收集细胞；②分别孵育一抗和二抗；③孵育 pA/pG-Tn5 转座子（Hyperactive pA/pG-Tn5 Transposon）；④激活转座子，进行 DNA 片段化；⑤DNA 提取；⑥文库扩增与纯化。 1. 细胞起始量低 投入不同起始量的 HEK293 细胞（ 100 或 10,000 个细胞），按照 Vazyme #TD901
原理基因组步行技术是一种新发展的利用已知序列(cDNA或基因组DNA)从基因组中获得基因的上游(如启动子)或下游序列的方法。其原理如下：首先利用不同的具有平末端的 DNA 限制性内切酶消化基因组 DNA，然后将预先设计好的 DNA 接头连接在 DNA 的两端。这样的一组两端带有接头的 DNA 片段就称为所谓的无载体的 DNA 文库；根据接头和目的基因的序列设计两组引物，以上述的DNA为模板，先以外侧的一组引物进行第一轮 TD-PCR (touchdownPCR )扩增，然后以内侧的一组引物进行
Stock solutions for tissue culture
The kitchen makes Tris, TD, Tryp/TD, PBS, and VE. Tris is a fairly complex, Tris-buffered physiological saline solution. It is used to wash cells and is preferable to TD, unless you need a Ca2+/Mg2+ free solution. It is: 136.8 mM NaCl
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