重组人热激因子结合蛋白-1(HSBP-1)

产品英文名称：
Recombinant Human Heat Shock Factor Binding Protein- 1

英文简称:
HSBP-1

中文名称:
重组人热激因子结合蛋白-1

背景资料:
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs （heat shock factors） results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein-1 （HSBP1）， is a 76-amino-acid protein that binds to heat shock factor 1（HSF1）， which is a transcription factor involved in the HS response. During HS response， HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe e大肠杆菌中重组表达ects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.

产品描述:
Recombinant Human HSBP1 produced in E.Coli is a single，non-glycosylated polypeptide chain containing 76 amino acids and having a molecular mass of 8.5 kDa.
来源宿主:
大肠杆菌中重组表达

溶解建议:
Sterile filtered colorless solution. The HSBP1 protein （1mg/ml） solution contains 20mM Tris-HCl buffer pH-7.5， 50mM NaCl， 1mM EDTA and 20% Glycerol.

保存建议：
Store at 4℃ if entire vial will be used within 2-4 weeks. Store， frozen at -20℃ for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles.
应用领域：
重组人热激因子结合蛋白-1产品可广泛应用于功能研究、蛋白互作研究、ELISA检测、Western Blot、免疫组化等生物医学研究领域。

关键词：
重组人热激因子结合蛋白-1、Recombinant Human Heat Shock Factor Binding Protein- 1、HSBP-1、重组蛋白、多肽、原核表达、CMBIO、淳麦生物

其他简介：

 
CMBIO