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- 文献和实验
- 技术资料
- 保存条件：
2-8度
- 保质期：
1年
- 英文名：
Thyroglobulin
- 库存：
999
- 供应商：
上海淳麦生物
- 规格：
/5ug/20ug/1mg
Human Thyroglobulin
英文简称:
Thyroglobulin
中文名称:
人甲状球蛋白
背景资料:
Thyroglobulin （TG） represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. TG is a large globular dimeric glycoprotein with a total molecular weight of 660 kDa， which occupies a key precursor role in the biosynthesis of the thyroid hormones. Approximately 75% of the total protein content of the thyroid follicle consists of TG. The thyroid gland uses the Thyroglobulin in order to produce the thyroid hormones thyroxine （T4） and trStore at 4℃ if entire vial will be used within 2-4 weeks. Store， frozen at -20℃for longer periods of time. Avoid multiple freeze-thaw cycles.odothyronine （T3）. Thyroglobulin is produced by the thyroid epithelial cells （thyrocytes） which form spherical follicles. Thyroglobulin is subsequently secreted and stored in the follicular lumen. Patients with Hashimoto’s thyroiditis or Graves’ disease， frequently develop antibodies against Thyroglobulin. Tg-specific antibodies help in the diagnosis of the above diseases， however they also may be present in apparently healthy euthyroid individuals. Blood Thyroglobulin levels can be used as a tumor marker for certain kinds of thyroid cancer， and the may also be elevated in cases of Graves’ disease.
产品描述:
Human Thyroglobulin is a glycosylated， polypeptide chain having a total molecular mass of 662 kDa.
来源宿主:
人甲状腺组织中提取纯化
溶解建议:
Human Thyroglobulin is supplied in 16mM HEPES buffer pH-7.6， 240mM sodium chloride， and 20% glycerol.
保存建议：
Store at 4℃ if entire vial will be used within 2-4 weeks. Store， frozen at -20℃for longer periods of time. Avoid multiple freeze-thaw cycles.
应用领域：
人甲状球蛋白产品可广泛应用于内分泌研究、免疫检测研究、抗体开发、ELISA检测、Western Blot、免疫组化等生物医学研究领域。
关键词：
人甲状球蛋白、Human Thyroglobulin、Thyroglobulin、多肽、抗原、激素、CMBIO、淳麦生物
其他简介：
CMBIO
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文献和实验脊椎动物甲状腺中大量存在的特异的含碘蛋白质。作为甲状腺激素的甲状腺素3， 5， 3′ -三碘甲腺原氨酸，是甲状腺内这种蛋白的酪氨酸残基经碘化所生成的碘化酪氨酸的两个残基，进一步缩合而生成的。这类激素需经蛋白酶作用于甲状腺球蛋白，使其变成游离态释放于血液中。由此可见，甲状腺球蛋白是甲状腺激素生成的场所，另也起着贮存型分子的作用。分子量约为 67万，等电点为 pH4.5左右。由于种属的不同，具有含碘量不相同的各种分子，其含量为 0.2-1%。除上述两种甲状腺激素含碘氨基酸残基外，还有二碘
Methods of Measuring Thyroglobulin and Peptide-Methylcoumarinamide Hydrolysis by Autoantibodies
was first discovered using human autoantibody mixtures (1 ,2 ). Thyroglobulin (Tg), a large water-soluble glycoprotein (mass approx 660 kDa) is a classical target for autoimmune responses. Thyroglobulin is stored in the thyroid colloid and can constitute up to 70
Methods for the Investigation of Thyroid Function
of free thyroxine. An equilibrium dialysis method is described. Methods for the measurement of TSH receptor antibodies and for thyroid peroxidase and thyroglobulin antibodies used in the assessment of autoimmune thyroid disease are given.
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