- 询价
- Miltenyi Biotec
- 德国
- 130-124-884
- 2025年12月09日
- Intracellular flow cytometry
- human cell line
- human, mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Notch1
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA357
- 标记物：
PE
- 适应物种：
human, mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Intracellular flow cytometry
- 浓度：
1:50
- 抗体英文名：
Notch1 Antibody, anti-human/mouse, REAfinity™
- 抗体名：
Notch1 Antibody, anti-human/mouse, REAfinity™
- 规格：
100 tests in 200 µL
Identification and enumeration of Notch1+ cells by flow cytometryClone REA357 recognizes the human and mouse neurogenic locus notch homolog protein 1 (notch1) antigen, a 300 kDa single-pass type I membrane protein also known as translocation-associated notch protein (TAN-1). Following cleavage in the Golgi, notch forms a heterodimer composed of a 180–200 kDa disulfide-linked extracellular domain (NEXT), and a 120 kDa membrane-bound intracellular portion (NICD). Upon ligand binding the latter is cleaved to form the notch intracellular domain transcription factor. Notch signaling controls cell fate decisions and is involved in multiple cellular differentiation steps during embryonic development and in adult organisms. In the immune system, notch1 plays a non-redundant role for thymic T cell development. Notch1 is also expressed by peripheral T cells and upregulated upon T cell activation. Clone REA357 recognizes the intracellular domain of mouse and human notch1, but not mouse notch2, 3, or 4. | Additional information: Clone REA357 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Weng, A. P. et al. (2004) Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306 (5694): 269–271. | Gray, G. E. et al. (1999) Human ligands of the Notch receptor. Am. J. Pathol. 154 (3): 785–794. | Arruga, F. et al. (2014) Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia. Leukemia 28 (5): 1060–1070.
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Notch1 Antibody, anti-human/mouse, PE, REAfinity™, 100 tests in 200 µL
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