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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
D-erythro-Dihydrosphingosine 1-phosphate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
1 mg
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Sphinganine 1-phosphate
CAS No. : 19794-97-9
MCE 国际站：Sphinganine 1-phosphate
产品活性：Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) 是一种极性鞘脂代谢物，可调节细胞迁移、细胞分化等众多生理过程。
研究领域：Metabolic Enzyme/Protease
In Vitro: Sphinganine 1-phosphate (S1P) is a potent signaling molecule involved in cell stress responses, cancer, angiogenesis and lymphocyte trafficking. Sphinganine 1-phosphate functions primarily by activating a subgroup of the endothelial differentiation gene (EDG) family of G-protein coupled cell surface receptors. Sphinganine 1-phosphate has opposite effects in the regulation of cell metabolism. Sphinganine 1-phosphate regulates skeletal muscle differentiation and regeneration.
Sphinganine 1-phosphate (S1P) is involved in cancer. Sphinganine 1-phosphate regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival.
Sphinganine-1-Phosphate (1 μM) phosphorylates ERK MAPK, Akt, and HSP27 and induces HSP27 in human renal endothelial cells.
In Vivo: Sphinganine 1-phosphate can enhance wound healing in diabetic mice. Sphinganine 1-phosphate provides renal and hepatic protection after liver ischemia and reperfusion (IR) injury in mice through selective activation of S1P1 receptors and pertussis toxin-sensitive G-proteins with subsequent activation of ERK and Akt. Sphinganine 1-phosphate (administered 0.1 mg/kg i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion) protects against hepatic and renal injury after liver IR.
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文献和实验as an endophyte of maize. Fumonisin is a potent inhibitor of the enzyme ceramide synthase, and this inhibition results in the accumulation of a variety of upstream compounds, most notably, the sphingoid bases sphingosine, sphinganine, 1-deoxysphinganine
三句话读懂一篇 CNS：饮酒引起 74 万新发癌症；干细胞研究为不孕不育患者带来福音……
，北京生命科学研究所蒋辉教授等团队在 Cell Metabolism 上发表研究论文 Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease。该研究发现了 NAD+ 再生通路 Glycerol-3-phosphate (Gro3P) biosynthesis，此通路在进化上保守，为神经退行性疾病提供了潜在的治疗靶点。图 5：来源 Cell Metabolism
CaPO4 Transfection for Chromaffin Cells
Na2HPO4-7H20 + 97.8 ml Store at 4'C (pH is >9, nothing will grow In it) 3. 2x PlBS 280 mM NaC1 1.84g 40 mM PIPES 1.21g 1.5 mM Na2HPO4 1.0 ml of 150 mM Na2HPO4 Dissolve components in approximately 80 ml H2O. AdJust pH to 6.95
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