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- Bioss
- IFN gamma Mouse mAb, AP conjugated(BSP0149D-AP)-100ul
- 2025年10月16日
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100ul
| 产品编号 | BSP0149D-AP |
| 英文名称 | IFN gamma Mouse mAb, AP conjugated |
| 英文别名 | Interferon gamma; Ifng; IFN-gamma; IFNγ |
| 产品应用 | ELISA=1:1000 Not yet tested in other applications. |
| 抗体来源 | Mouse |
| 免疫原 | A synthesized peptide derived from IFNG |
| 亚型 | IgG2b |
| 性状 | Liquid |
| 纯化方法 | Affinity Purification |
| 克隆类型 | Monoclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Tumor immunology > Cytokines > Interferons Immunology > Adaptive Immunity > Regulatory T Cells Immunology > Innate Immunity > Cytokines > Interferons Stem Cells > Signaling Pathways > TGF beta > Interferon gamma |
| 亚基 | Homodimer. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Released primarily from activated T lymphocytes. |
| 翻译后修饰 | Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161. |
| 相似性 | Belongs to the type II (or gamma) interferon family. |
| 功能 | Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Mammalian Interferon gamma is mainly produced by T lymphocytes and NK cells. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses,including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. It has weak antiviral and antiproliferative activity, and poteniates the antiviral and anti tumor effects of IFN alpha / beta (type I interferon). It is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. Labile at pH 2. |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:1000} |
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文献和实验tumor necrosis factor–{alpha} (TNF-{alpha}), interferon-beta (IFN-beta), and IFN-{gamma} (1). The authors observed that of ~200 miRNAs examined, only miR-155 increased in amount in response to both TLR ligands and IFN-beta. miR-155 accumulated
Rapid Inactivation of Proteins by Knocksideways
with an FKBP domain knocked into its AP‐1 gamma gene ( AP1G1 ) were transiently transfected with Mitotrap, incubated with rapamycin for 10 min, and labeled for AP‐1 gamma. Scale bars: 10 µm. View Image
TRAF‐Mediated TNFR‐Family Signaling
, A.M., Dowd, A.D., Brush, A.D., Heldens, A.D., Schow, A.D., Goddard, A.D., Wood, W.I., Baker, K.P., Godowski, P.J., and Ashkenazi, A. 1999. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse
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