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- Bioss
- bs-14552P
- 2026年10月10日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-14552P |
| 英文名称 | EIF4G3 Antibody Blocking Peptide |
| 中文名称 | eIF4GII蛋白封闭多肽 |
| 英文别名 | eIF-4-gamma 3; eIF-4-gamma II; eIF-4G 3; eIF4G 3; EIF4G3; eIF4GII; Eukaryotic translation initiation factor 4 gamma 3; eukaryotic translation initiation factor 4 gamma, 3; eukaryotic translation initiation factor-4 gamma, 3; IF4G3_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > Translation > Regulation |
| 亚基 | Interacts with EIF4A, EIF4E, eIF3 and PABPC1. Part of a complex with EIF4E. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA (By similarity). |
| 翻译后修饰 | Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription. |
| 相似性 | Belongs to the eukaryotic initiation factor 4G family. _x000D_ Contains 5 HEAT repeats. _x000D_ Contains 1 MI domain. _x000D_ Contains 1 MIF4G domain._x000D_ Contains 1 W2 domain. |
| 功能 | Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Translation initiation in eukaryotes necessitates the assembly of an 80S ribosomal complex. Eukaryotic initiation factors (eIFs) are utilized in a sequence of reactions that leads to 80S ribosomal assembly and initiation of translation. Mammalian eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that contains eIF4A, eIF4E and eIF4G, binds mRNA at a 5’-cap motif and recruits the 43S ribosomal preinitiation complex to the transcript. Along with eIF4B, the eIF4F complex mediates the unwinding of mRNA secondary structure to facilitate ribosome association. eIF4E specifically interacts with the 5’ cap, eIF4A is a bidirectional RNA helicase, and eIF4GI and eIF4GII are scaffolding proteins which coordinate eIF4E, eIF4A, eIF3 and the 40S ribosome. eIF4GII (also known as eIF4G3 and eIF4-g3) is a 1,585 amino acid protein that is 46% homologous and functionally similar to eIF4GI. |
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EIF4G3 | eIF4GII Ab Blocking Peptide(bs-14552P)-500ug
￥880
