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- bs-23394P
- 2025年10月16日
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500ug
| 产品编号 | bs-23394P |
| 英文名称 | GCLC Antibody Blocking Peptide |
| 中文名称 | γ谷氨酰半胱氨酸合成酶封闭多肽 |
| 英文别名 | Gamma ECS; Gamma GCS; Gamma glutamylcysteine synthetase; Gamma-ECS; Gamma-glutamylcysteine synthetase; GCL; GCLC; GCS; GCS Heavy Chain antibody GLCL; GLCLC; GLCLR; Glutamate cysteine ligase catalytic subunit; Glutamate cysteine ligase (gamma glutamylcysteine synthetase) regulatory (30.8kD); Glutamate cysteine ligase catalytic subunit; Glutamate cysteine ligase modifier subunit; Glutamate cysteine ligase regulatory protein; Glutamate cysteine ligase regulatory subunit; Glutamate--cysteine ligase catalytic subunit; GSH1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Other Antibodies > Other Antibodies Cell Biology > Other Antibodies > Oxidative Stress Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress Signal Transduction > Metabolism > Mitochondrial |
| 亚基 | Heterodimer of a catalytic heavy chain and a regulatory light chain. |
| 相似性 | Belongs to the glutamate--cysteine ligase type 3 family. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The GCLC gene consists of 16 exons and encodes the 636 amino acid protein g-GCSc (g-glutamylcysteine synthetase heavy subunit), also designated g-L-glutamate-L-cysteine ligase catalytic subunit (GLCLC). g-GCSc is expressed in hemocytes, brain, liver and kidney. g-GCSc associates with a regulatory or modifier subunit, g-GCSm (g-glutamylcysteine synthetase light subunit), to form a heterodimer, g-GCS. g-GCS is the first enzyme involved and the rate determining step in glutathione biosynthesis. Oxidants, cadium and methyl mercury upregulate the transcription of g-GCS. H2O2 regulation depends on the Yap1 protein and the presence of glutamate, glutamine and lysine. Cadium regulates transcription through proteins Met-4, Met-31 and Met-32. Cbf1, a DNA binding protein, inhibits transcription of g-GCS. Chemopreventive compounds cause increased levels of g-GCSc in kidney tissues, which may protect against chemically induced carcinogenesis. A His370Leu amino acid change in g-GCSc causes deficiencies in activity which are responsible for hemolytic anemia and low red blood cell glutathione levels. Defects in GCLC are the cause of hemolytic anemia. |
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GCLC Antibody Blocking Peptide(bs-23394P)-500ug
￥880
