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| 产品编号 | bs-3800P |
| 英文名称 | Kappa Light Chain Antibody Blocking Peptide |
| 中文名称 | k轻链封闭多肽 |
| 英文别名 | Kappa Light Chain; IGKC; HCAK 1; HCAK1; Ig kappa chain C region; IGKC; Immunoglobulin kappa constant; Immunoglobulin kappa constant region; Immunoglobulin kappa light chain; Kappa 1 immunoglobulin light chain; Km; MGC111575; MGC62011; MGC72072; MGC88770; MGC88771; MGC88809; Human Ig/L-Chain Kappa; IGKC_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Immunoglobulins > Light Chain > Kappa |
| 亚细胞定位 | Cytoplasmic and Secreted. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Immunoglobulins belong to a group of related glyco proteins which make up 20% of serum proteins. Antigens and immunoglobulins react to confer immunity to individuals. Immunoglobulins have similar structures of two identical heavy chains and two identical light chains. Both the heavy chains and the light chains are divided into constant and variable regions. The constant regions have the same amino acid sequences between all the immunoglobulin classes. The variable regions have approximately 110 amino acids with high sequence variability. The amino acid sequence of the heavy chain determines the class of an immunoglobulin. The five types of immunoglobulin heavy chains are known as: IgG, IgA, IgM, IgD, and IgE. IgG is divided into four subclasses, and IgA is divided into two subclasses. In serum IgA and IgG are monomers with a single 4 polypeptide unit; while, IgM is a pen tamer. IgA may also form polymers. Kappa light chain antibody can be used for the identification of leukemias, plasmacytomas and certain non Hodgkin's lymphomas. Kappa light chain contains one immunoglobulin like domain. The EU sequence has the INV allotypic marker, Ala 45 and Val 83. The ROY sequence has the INV allotypic marker, Ala 45 and Leu 83. |
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文献和实验）。 图2-3 免疫球蛋白分子的基本结构示意图 （一）轻链和重链 由于骨髓瘤蛋白（M蛋白）是均一性球蛋白分子，并证明本周蛋白（BJ）是Ig分子的L链，很容易从患者血液和尿液中分离纯化这种蛋白，并可对来自不同患者的标本进行比较分析，从而为Ig分子氨基酸序列分析提供了良好的材料。 1．轻链（light chain,L） 轻链大约由214个氨基酸残基组成，通常不含碳水化合物，分子量约为24kD。每条轻链含有两个由链内二硫键内二硫所组成的环肽。L链共有两型：kappa(κ
【申请上传】Current Protocols in Immunology
Chapter 17 Engineering Immune Molecules and Receptors Introduction Unit 17.1 Bacteriophage Library Construction and Selection of Recombinant Antibodies Unit 17.2 Monitoring Antigen-Specific T Cells Using MHC-Ig Dimers Unit 17.3 MHC-Peptide Tetramers
缩写 全称 中文 AA autoantibody 自身抗体 AAF aminoacetylfluorescence 氨乙酰基荧光 Ab antibody 抗体 ABC avidin-biotin peroxidase complex 抗生物素（亲合素）-生物素-过氧化物酶复合物 ACh acetycholine 乙酰胆碱 AChR acetycholine receptor 乙酰胆碱受体 AChRAb acetycholine
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