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- 2025年10月16日
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500ug
| 产品编号 | bs-3800P |
| 英文名称 | Kappa Light Chain Antibody Blocking Peptide |
| 中文名称 | k轻链封闭多肽 |
| 英文别名 | Kappa Light Chain; IGKC; HCAK 1; HCAK1; Ig kappa chain C region; IGKC; Immunoglobulin kappa constant; Immunoglobulin kappa constant region; Immunoglobulin kappa light chain; Kappa 1 immunoglobulin light chain; Km; MGC111575; MGC62011; MGC72072; MGC88770; MGC88771; MGC88809; Human Ig/L-Chain Kappa; IGKC_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Immunoglobulins > Light Chain > Kappa |
| 亚细胞定位 | Cytoplasmic and Secreted. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Immunoglobulins belong to a group of related glyco proteins which make up 20% of serum proteins. Antigens and immunoglobulins react to confer immunity to individuals. Immunoglobulins have similar structures of two identical heavy chains and two identical light chains. Both the heavy chains and the light chains are divided into constant and variable regions. The constant regions have the same amino acid sequences between all the immunoglobulin classes. The variable regions have approximately 110 amino acids with high sequence variability. The amino acid sequence of the heavy chain determines the class of an immunoglobulin. The five types of immunoglobulin heavy chains are known as: IgG, IgA, IgM, IgD, and IgE. IgG is divided into four subclasses, and IgA is divided into two subclasses. In serum IgA and IgG are monomers with a single 4 polypeptide unit; while, IgM is a pen tamer. IgA may also form polymers. Kappa light chain antibody can be used for the identification of leukemias, plasmacytomas and certain non Hodgkin's lymphomas. Kappa light chain contains one immunoglobulin like domain. The EU sequence has the INV allotypic marker, Ala 45 and Val 83. The ROY sequence has the INV allotypic marker, Ala 45 and Leu 83. |
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文献和实验Display of Antibody Chains on Filamentous Bacteriophage
for immunotherapy. Combinations of randomly assembled pairs of immunoglobulin heavy (H) and light (L) chain genes are cloned and expressed as fusions of bacteriophage coat proteins, allowing the bacteriophage expressing them to be selected by methods analogous
Selection of Human Immunoglobulin Light Chains from a Phage-Display Library
may be a pathogenetic factor in asthma. With the aim of investigating the possible cause-effect relationship between autoantibodies to VIP and asthma, we have cloned catalytic antibody light (L) chains from the immune repertoire of an exercise-induced asthma patient
Notes on Making Rat x Y3 Monoclonal Antibody Producing Hybridomas
to the kappa 1a of Y3 (eg. DA which is kappa 1b) to allow later screening of myeloma light chain loss variants (if required). b) The final boost should be by the intravenous route, four days before the fusion, to ensure maximal activity in the spleen.
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