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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant human IL-1RAPL1 protein
- 亚型:
IgG
- 保存条件:
Store at -20°C. Stable for one year after shipment.
- 克隆性:
Polyclonal
- 标记物:
Unconjugated
- 适应物种:
human, mouse, rat
- 保质期:
详见产品包装
- 库存:
充足
- 宿主:
Rabbit
- 应用范围:
WB, IHC, IF-P, ELISA
- 靶点:
IL-1-RAPL-1
- 抗体英文名:
IL-1-RAPL-1 Polyclonal antibody
- 抗体名:
IL-1-RAPL-1 Polyclonal antibody
- 规格:
50ul/100ul/150ul
| 规格: | 50ul | 产品价格: | ¥1350.0 |
|---|---|---|---|
| 规格: | 100ul | 产品价格: | ¥2200.0 |
| 规格: | 150ul | 产品价格: | ¥3000.0 |
经过测试的应用
| Positive WB detected in | fetal human brain tissue, mouse brain tissue, rat brain tissue |
| Positive IHC detected in | mouse brain tissue, rat brain tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse brain tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:6000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
21609-1-AP targets IL-1-RAPL-1 in WB, IHC, IF-P, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, IHC, IF-P, ELISA |
| 文献引用应用 | WB, IF |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse |
| 免疫原 |
CatNo: Ag16252 Product name: Recombinant human IL-1RAPL1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 552-696 aa of BC126345 Sequence: WKRLQYEMPFKRIEPITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQMRQKHYYRSYEYDVPPTGTLPLTSIGNQHTYCNIPMTLINGQRPQTKSSREQNPDEAHTNSAILPLLPRETSISSVIW |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | interleukin 1 receptor accessory protein-like 1 |
| 别名 | IL1RAPL1, EC:3.2.2.6, IL 1 RAPL 1, IL 1RAPL 1, IL1R8 |
| 计算分子量 | 696 aa, 80 kDa |
| 观测分子量 | 80-100 kDa |
| GenBank蛋白编号 | BC126345 |
| 基因名称 | IL-1-RAPL-1 |
| Gene ID (NCBI) | 11141 |
| RRID | AB_10888632 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9NZN1 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
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文献和实验| Species | Application | Title |
|---|---|---|
| human | WB | Mol Cell AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay.Authors - Hana Cho
|
Allergy Skewed inflammation is associated with aberrant interleukin-37 signaling pathway in atopic dermatitis.Authors - Tianheng Hou | ||
| human | WB | EMBO J Splice-dependent trans-synaptic PTPδ-IL1RAPL1 interaction regulates synapse formation and non-REM sleep.Authors - Haram Park |
| human | WB | Cell Death Dis IL-37 isoform D downregulates pro-inflammatory cytokines expression in a Smad3-dependent manner.Authors - Mingsheng Zhao
|
| mouse,human | WB,IF | J Neurosci The X-linked intellectual disability protein IL1RAPL1 regulates dendrite complexity.Authors - Caterina Montani
|
Cell Rep IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.Authors - Yingying Han |
细胞CSF(GM-CSF)、多重集落刺激因子(multi-CSF,又称IL-3)、干细胞因子(SCF)、红细胞生成素(EPO)。有人将IL-5称为嗜酸性粒细胞集落刺激因子(Eo-CSF)。此外,IL-1、IL-6和IL-11在骨髓多能干细胞早期的分化中也有重要的作用。 (一)IL-3 1981年Ihle等发现ConA刺激小鼠脾细胞的培养上清中含有一种因子,能提高裸鼠脾脏淋巴细胞成熟淋巴细胞标志20-α-羟固醇脱氢酸(20-α-hydroxysteriod dehydrogenase,20
常重要的,这些细胞系仅在TCR介导的信号以及IL-1共同作用下才出现IL-2基因的转录。PHA刺激c-fos转录,IL-1刺激c-jun转录,因此,PHA和IL-1可以诱导AP-1核因子的出现(见图8-13)。在正常T细胞中情况更加复杂,IL-2基因的转录可能还需要其它的核因子参与。T细胞中细胞子基因转录的一个明显的特点是它们对免疫抑 制药 CsA的作用非常敏感,CsA主要是通过抑制T细胞因子的产生起免疫抑制作用的,从而抑制T细胞生长和效应功能,IL-2基因增强子区域是CsA
IB Kinase and NF-B Signaling in Response to Pro-Inflammatory Cytokines
Exposure to pro-inflammatory cytokines (TNFα and IL-1) results in activation of signaling cascades that lead to stimulation of activity of the transcription factors AP-1 and NF-κB and induction of genes that are controlled
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