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- bs-6028R-Cy5
- 2026年05月21日
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| 产品编号 | bs-6028R-Cy5 |
| 英文名称 | CD16 Rabbit pAb, Cy5 conjugated |
| 中文名称 | Cy5标记的FC段γ受体3/免疫球蛋白G Fc段受体III抗体 |
| 英文别名 | FCG3A_HUMAN; Low affinity immunoglobulin gamma Fc region receptor III-A; CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: D16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3. |
| 产品应用 | IF=1:100-500, ICC/IF=1:100-500, Flow-Cyt=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human IGFR3/CD16 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Cell Type Markers > CD > NK Cells Stem Cells > Hematopoietic Progenitors > Hematopoietic Stem Cells > Human Lineage Negative Stem Cells > Hematopoietic Progenitors > Lymphoid > NK Cell Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Monocytic Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Neutrophil Lineage |
| 亚基 | Exists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. Interacts with INPP5D/SHIP1. |
| 亚细胞定位 | Cell membrane. Secreted. Exists also as a soluble receptor. |
| 组织特异性 | Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts. |
| 翻译后修饰 | Glycosylated. Contains high mannose- and complex-type oligosaccharides. The soluble form is produced by a proteolytic cleavage. [MISCELLANEOUS] Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed in a tissue-specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the 'Ser-203' in III-B determines the GPI-anchoring. |
| 相似性 | Contains 2 Ig-like C2-type (immunoglobulin-like) domains. |
| 功能 | Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020] |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {Flow-Cyt} | {1:100-500} |
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文献和实验方案，用于检测不同免疫细胞亚群： 种属 细胞群 流式抗体搭配 货号 Human T/B/NK细胞群检测 CD45-PerCP PCP-30039 CD3-FITC FITC-30004 CD16-PE PE-30061 CD56-PE PE-30008 CD19-APC APC-30066 Human Th1/Th2 细胞群检测 CD3-PerCP-Cy5.5 PCP55-30004 CD4-FITC FITC-30005 IFN-γ-PE PE-30053
免疫细胞与基质细胞。 首先，在FSC-A vs SSC-A图中通过R0圈定计数微球用于定量，并利用R1门排除碎片杂质。 接着进行谱系分离：在R1门内依据CD45、CD326及CD31的表达差异，将细胞精准划分为白细胞（R2）、上皮细胞（R3）和内皮细胞（R4），有效区分了造血细胞与结构细胞。 最后，对各亚群进行死活染料（FVD）分析，剔除死细胞（R5），从而获得存活的白细胞（R6）、上皮细胞（R7）及内皮细胞（R8）。 这套“去碎片-分谱系-除死细胞”的严密流程，为后续肿瘤微环境研究提供了高纯
！ 以下是菲恩生物推荐的流式抗体搭配方案 种属 细胞群 流式抗体搭配 货号 Human T/B/NK细胞群检测 CD45-PerCP PCP-30039 CD3-FITC FITC-30004 CD16-PE PE-30061 CD56-PE PE-30008 CD19-APC APC-30066 Human Th1/Th2 细胞群检测 CD3-PerCP-Cy5
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