- ￥970
- Proteintech
- 65248-1-Ig
- 2025年10月09日
- FC
- Mouse
- human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgM, kappa
- 保存条件：
Store at 2-8°C. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
human
- 宿主：
Mouse
- 应用范围：
FC
- 靶点：
CD36
- 抗体英文名：
Anti-Human CD36 (SMΦ)
- 抗体名：
Anti-Human CD36 (SMΦ)
- 规格：
100ug
经过测试的应用
| Positive FC detected in | human peripheral blood platelets |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Flow Cytometry (FC) | FC : 0.2 ug per 10^6 cells in 100 μl suspension |
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
65248-1-Ig targets CD36 in FC applications and shows reactivity with human samples.
| 经测试应用 | FC |
| 文献引用应用 | FC |
| 经测试反应性 | human |
| 文献引用反应性 | human |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Mouse / IgM, kappa |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | CD36 molecule (thrombospondin receptor) |
| 别名 | PAS 4, GPIV, GPIIIB, GP4, GP3B |
| 计算分子量 | 472 aa, 53 kDa |
| GenBank蛋白编号 | BC008406 |
| 基因名称 | CD36 |
| Gene ID (NCBI) | 948 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Affinity purification |
| UNIPROT ID | P16671 |
| 储存缓冲液 | PBS with 0.09% sodium azide, pH 7.3. |
| 储存条件 | Store at 2-8°C. Stable for one year after shipment. |
背景介绍
CD36, also named as GP3B and GP4, is an 88-kDa membrane glycoprotein present on platelets, monocytes, erythroid precursors, endothelial cells, and several tumor cell lines. CD36 binds to collagen, thrombospondin, anionic phospholipids, long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport and oxidized LDL. CD36 may function as a cell adhesion molecule. It mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Mutation of CD36 will cause platelet glycoprotein IV deficiency which known as CD36 deficiency. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7).
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文献和实验| Species | Application | Title |
|---|---|---|
| human | FC | Eur J Pharmacol Obacunone Potentiated PD-1 Immunotherapy in Pancreatic Cancer by Mediating CD36Authors - Chun-Yan Sang |
erythrocytes to microvascular endothelial cells CD36 deficiency frequent in sub-Saharan Africa, Asia; associated surprisingly with susceptibility to severe cerebral malaria Development of anti-CD36 antibodies can cause serious complications
转换（class switch） 是指一个B细胞克隆在分化过程中，V基因不变，而CH基因片段不同重排，比较CH基因片段重排后基因编码的产物，其V区相同，而C区不同，即识别抗原的特异性相同，而Ig的类或亚类发生改变。Ig可能是通过缺失模式（deletion model）和RNA剪接（splicing）两种机制来实现类别的转换。 （三）膜表面Ig重链基因 膜表面Ig（Sm Ig）是B细胞识别抗原的受体。(Sm Ig)和分泌性Ig的H链结构相类似，所不同的是smIgH名字的羧基端多含一段穿膜的疏水
网络 二、Ig超家族的特点 （一）Ig超家族的结构特点 Ig超家族成员均含有1～7个Ig样结构域，每个Ig样结构域约含70～110个氨基酸残基。其二级结构是两个各含3～5个反平行β折叠股所形成的β片层（anti-parallel β-pleated sheet)平面，每个反平行β折叠股由5～10个氨基酸残基组成，β
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