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        CD36分子

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        2874
        CD36 分子
        CD36
         
        常用单克隆抗体或代号: 5F1,ESIVC7,OKM5
        主要表达细胞: Pt,M,Mac, (B) [Pt]
        分子质量(kDa)和结构: gp88,血小板GPⅣ
        功    能: 结合ECM(CA、Thr),血小板粘附
         
        CD36
        Aka platelet GPIV or GPIIIb; thrombospondin receptor
        Scavenger receptor for 50% of oxidized LDL and shed photoreceptor outer segments
        Cell adhesion molecule in platelet adhesion and aggregation, platelet-monocyte and platelet-tumor cell interaction
        Site of cytoadherence of Plasmodium falciparum infected erythrocytes to microvascular endothelial cells
        CD36 deficiency frequent in sub-Saharan Africa, Asia; associated surprisingly with susceptibility to severe cerebral malaria
        Development of anti-CD36 antibodies can cause serious complications in multiply transfused patients (sickle cell disease)
        Positive staining (normal): platelets, macrophages, endothelial cells, early erythroid cells, megakaryocytes
        Positive staining (disease): AML M4-M7
        Negative staining: AML M0-M2 (usually), M3

         
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