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文献和实验Purification and Characterization of Human Serum and Secretory IgA1 and IgA2 Using Jacalin
). Most of the IgA in secretions (sIgA) is polymeric, predominantly dimeric, comprising two monomer subunits linked together by intersubunit disulfide bonds and a cysteine-rich polypeptide termed J-chain (M r
和肠系膜淋巴细胞的浆细胞。另一种是与分泌成分(secretory component, SC)结合的二聚体,即SIgA,沉降系数为11S,主要存在唾液、初乳及胃肠道等分泌液中。成人肠道每天能分泌3gSIgA。目前多认为胃肠道是s IgA的中枢器官。SIgA由SC、J链和二个IgA单体组成,形成过程包括:SC的合成、J链和IgA合成、IgA与SC结合和SIgA分泌。SC是分子量为83000dalton左右的糖蛋白,由549~558个氨基酸和20%糖组成,其转录基因在上皮细胞的第1对染色体上。我们用免疫
Detection and Quantitation of Antifungal SIgA Antibodies in Body Fluids
. The principal immunoglobulin isotype in mucosal secretions is secretory immunoglobulin A (SIgA). Unlike the circulatory system, mucosal surfaces are open systems in which the concentrations of immune factors are affected by diurnal variation, changes in flow
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