- ￥567
- Sigma-Aldrich
- 进口
- SML0889-5MG
- 2025年09月04日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
−20°C
- 保质期：
根据瓶身LOT号查询
- 英文名：
bpV(phen)
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
42494-73-5
- 规格：
5MG
属性
质量水平
100
方案
≥95% V basis
表单
powder
储存条件
protect from light
颜色
faintly yellow to dark yellow
溶解性
H2O: 20 mg/mL, clear
储存温度
−20°C
SMILES字符串
O=[V]123([N]4=CC=CC5=C4C6=C(C=CC=[N]62)C=C5)(OO3)OO1.[K]
InChI
1S/C12H8N2.K.2H2O2.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;2*1-2;;/h1-8H;;2*1-2H;;/q;+1;;;;
InChI key
MQPXOTNOFVCXDA-UHFFFAOYSA-N
生化/生理作用
其他说明
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文献和实验A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity.
The inhibition of protein tyrosine phosphatases 1B (PTP1B) and N2 (PTPN2) has emerged as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a PTP1B/PTPN2 inhibitor in clinical trials for solid tumors. Here we have explored the therapeutic potential of a related small-molecule-inhibitor, Compound-182. We demonstrate that Compound-182 is a highly potent and selective active site competitive inhibitor of PTP1B and PTPN2 that enhances T cell recruitment and activation and represses the growth of tumors in mice, without promoting overt immune-related toxicities. The enhanced anti-tumor immunity in immunogenic tumors can be ascribed to the inhibition of PTP1B/PTPN2 in T cells, whereas in cold tumors, Compound-182 elicited direct effects on both tumor cells and T cells. Importantly, treatment with Compound-182 rendered otherwise resistant tumors sensitive to α-PD-1 therapy. Our findings establish the potential for small molecule inhibitors of PTP1B and PTPN2 to enhance anti-tumor immunity and combat cancer.
蒸馏水到960ml，调PH到4.6，最后加蒸馏水到总体积1000ml （2）AEC（20X） AEC 15mg/ml，溶在DMF（二甲基甲酰胺，分子式HCOH(CH3)2 分子量73.10中） （3）0.6% H2O2（20X） 临用时，（1）（2）（3）各50ul，在1ml双蒸馏水中混匀30分钟内有效。 7、DAB（即DAB-4HCL） （1）1.5克DAB在100ml水溶液中（20X） （2）1M Tris（20X），用HCL调PH到7.4
Fibronectin Sigma F0895-2MG Glass Bottle (250ml) with Cap Cole Parmer Instrument Co. 34594
minutes and the pellets were washed with PBS. After resuspension with 1 ml PBS, the cells were incubated with 10 ml of RNase I (10 mg/ml) and 100 ml of propidium iodide PI (400 mg/ml; Sigma) and shaken for 1 hour at 37ºC in the dark [20]. Samples
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