- ￥480 - 1600
- Solarbio|ActivAb
- 北京
- K111291P
- 2025年08月20日
- IHC;WB
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
A synthetic peptide of human BCAR3
- 亚型：
IgG
- 保存条件：
Store at -20℃. Avoid freeze/thaw cycles.
- 克隆性：
Polyclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Human
- 抗原来源：
A synthetic peptide of human BCAR3
- 目录编号：
8412
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
IHC;WB
- 浓度：
WB 1:1000-3000.;IHC 1:50-200.
- 靶点：
BCAR3
- 抗体英文名：
Anti-BCAR3 Polyclonal Antibody
- 抗体名：
乳腺癌抗雌激素抗性蛋白3抗体
- 规格：
20ul/100ul/50ul
| 规格： | 20ul | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 规格： | 50ul | 产品价格： | ￥960.0 |
| 基本信息 | |
| 英文名称 | Anti-BCAR3 Polyclonal Antibody |
| 中文名称 | 乳腺癌抗雌激素抗性蛋白3抗体 |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 交叉反应 | Human |
| 应用 | IHC;WB |
| 稀释比例 | WB 1:1000-3000.;IHC 1:50-200. |
| 密度 | |
| 靶标 | BCAR3 |
| 别名 | BCAR 3,BCAR3,BCAR3_HUMAN,Breast cancer anti estrogen resistance 3,Breast cancer anti estrogen resistance protein 3,Breast cancer anti-estrogen resistance protein 3,Breast cancer antiestrogen resistance 3,dJ1033H22.2,dJ1033H22.2 breast cancer anti estrogen resistance 3,dJ1033H22.2 breast cancer antiestrogen resistance 3,KIAA0554,Novel SH2 containing protein 2,Novel SH2-containing protein 2,NSP 2,NSP2,SH2 containing protein Nsp2,SH2 domain containing protein 3B,SH2 domain-containing protein 3B,SH2D3B |
| 背景说明 | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). |
| Swiss Prot | O75815 |
| Gene ID | 8412 |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | A synthetic peptide of human BCAR3 |
| Public Immunogen Range | 430-480/825aa |
| 理论分子量 | 56/82/93kDa |
| EC | |
| 纯化方法 | Affinity purification |
| 储存液 | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| 储存条件 | Store at -20℃. Avoid freeze/thaw cycles. |
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文献和实验Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
a simple ELISA method to detect human anti-antibody response.
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