- ￥1316.26
- BioLegend
- 320907
- 美国
- 2025年08月18日
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
APC anti-human MICA/MICB
- 抗体英文名：
APC anti-human MICA/MICB
- 供应商：
上海善然生物科技有限公司
- 保存条件：
2-8℃
- 规格：
25tests
APC anti-human MICA/MICB Antibody
6D4
Catalog# / Size 320907 / 25 tests
Clone
Regulatory Status RUO
Other Names PERB11, MIC, MHC class I chain-related protein A, MICA, PERB11.1, MHC class I chain-related
protein B, MICB, PERB11.2
Isotype Mouse IgG2a, κ
Description 6D4 antibody reacts with a common epitope of the human nonclassical MHC class I chainrelated protein A (MICA) and B (MICB), also known as PERB11.1 and PERB11.2. The MIC
gene is located in MHC class I region. MICA/B are 65-75 kD stress-inducible glycoproteins
with highly polymorphic. They are MHC class I-like transmembrane molecules that do not
associate β2-microglobulin and do not present peptides. MICA and MICB share 85% identify,
and are mainly expressed on Intestinal epithelial cells, epithelial tumor cells, endothelial cells,
fibroblasts, and IFN-α-stimulated dendritic cells. MIC molecules bind NKG2D, an activating
receptor, and induce activation of NK cells, and subset of CD8 α/β T cells and γ/δ T cells, as
well as suppression of T cell proliferation. MICA/B recognition is involved in the regulation of
tumor surveillance, viral infection and autoimmune diseases. The 6D4 antibody is able to block
MIC mediated cytotoxicity
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文献和实验Stimulation of Anti-HIV-1 Cytotoxic T Lymphocytes by Dendritic Cells
Dendritic cells (DC) are highly specialized antigen-presenting cells (APC) in both primary and secondary T-cell responses. This may be related to their expression of high levels of MHC class I and II antigens (1 -4 ), costimulatory
Approaches to Proteomic Analysis of Human Tumors
The involvement of tumor suppressor genes (TSG) in cancer initiation and progression is well documented in several tumor types such as colon (APC, p53) and breast (BrcA1, BrcA2) cancers. Loss of heterozygosity of distinct chromosomal regions
Molecular Typing of the MHC Class I Chain-Related Gene Locus
The human major histocompatibility complex (MHC) class I chain-related genes A and B (MICA and MICB ) are located within the human leukocyte antigen (HLA) class I region of chromosome 6 (1 ). Their organization, expression, and products
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