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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
Biotin anti-mouse IL-33Rα (IL1RL1, ST2)
- 抗体英文名：
Biotin anti-mouse IL-33Rα (IL1RL1, ST2)
- 供应商：
上海善然生物科技有限公司
- 库存：
现货
- 保存条件：
冷藏
- 规格：
100ug
Clone
DIH9
Regulatory Status RUO
Other Names T1/ST2, ST2L, IL-1R1, T1, DER4, IL1R1
Isotype Rat IgG2a, κ
Description IL-33Rα, also known as ST2 or IL-1RL1, is a member of the Toll/IL-1 receptor family. It binds
IL-33 and is structurally similar to IL-1R1. Two forms of the protein exist - a soluble form
known as ST2 and a membrane anchored form known as ST2L. The membrane form is
expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is
expressed by serum-stimulated fibroblasts.
Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and
airway inflammation. The IL-33-ST2 axis has been reported to be important across a range of
diseases including asthma, allergies, and cardiac disease.
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文献和实验白细胞介素 IL-33 IL-33主要产生细胞：黏膜等多种组织细胞 IL-33氨基酸数目：270／266 IL-33分子质量(kDa)：30／29．9 IL-33受体：IL-1受体；ST2 IL-33主要生物学活性：激活NFκB和MAPK途径，促进Th2细胞表达IL-4、1D5和IL-l3
A number of endogenously biotinylated proteins are found in both cytosol and mitochondria of mammalian cells from many tissues, including liver, spleen, pancreas, kidney, and intestine. Therefore, caution should be taken when using the biotin
in the nucleus in human cell cultures we designed several RNA-biotin based pulldown assays which can be used alone or in combination with other known assays such as ChIP and Flag-tagged pulldown assays. Three protocols are explained
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