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- BioLegend
- 120606
- 美国
- 2025年08月14日
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
PE anti-mouse LPAM-1 (Integrin α4β7)
- 抗体英文名：
PE anti-mouse LPAM-1 (Integrin α4β7)
- 供应商：
上海善然生物科技有限公司
- 保存条件：
2-8℃
- 规格：
200ug
PE anti-mouse LPAM-1 (Integrin α4β7) Antibody
DATK32
Catalog# / Size
120606 / 200 µg
Clone
Regulatory Status RUO
Other Names α4β7 Integrin, CD49d/β7, LPAM-1, ITGA4, ITGB7
Isotype Rat IgG2a, κ
Description DATK32 antibody is specific for a combinatorial determinate of integrin α4β7complex. Integrin α4β7 is
composed of a 150 kD (α4 or CD49d) and a 130 kD (β7) heterodimer, also known as CD49d/β7 or
LPAM-1. Belonging to the Ig superfamily, it is found on the majority of peripheral lymphocytes and
subsets of thymocytes and bone marrow cells (including mast cell progenitors). Integrin α4β7 binds its
ligands, VCAM-1 (CD106), MAdCAM-1 and fibronectin, and plays an important role in lymphocytes
adhesion and the direction of migration of blood lymphocytes to the intestine and associated lymphoid
tissues.
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文献和实验T-cell dependent antigen specific in situ staining (Pe)
6- Wash twice in TBS-T. 7- counterstain with rabbit anti B-Pe 1:2000 (0.5 µg/ml Cortex Biochem). You may add 1% mouse serum to the anti-Pe antibodies, unless you plan to use mouse monoclonal further (see below). 8- wash twice in TBS-T. 9- block
the opportunity to directly monitor new therapies. In this chapter, we describe a protocol to image, the in vivo distribution of the integrin β7 , expressed by lymphocytes recruited to and retained by the inflamed gut, using a radiolabeled whole antibody
Analysis of Integrin-Dependent Rapid Adhesion Under Laminar-Flow Conditions
stress that opposes leukocyte stable arrest on the endothelium. As the rapidness of integrin activation is mandatory to leukocyte adhesion to the blood vessels, any analysis of adhesion triggering relevant to leukocyte in vivo migration
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