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- 详细信息
- 文献和实验
- 技术资料
- 抗体名:
Anti-β-Amyloid, 17-24
- 抗体英文名:
Anti-β-Amyloid, 17-24
- 供应商:
上海善然生物科技有限公司
- 保存条件:
2-8℃
- 规格:
50ul
Anti-β-Amyloid, 17-24 Antibody (Previously Covance catalog# SIG-39200)
4G8
Catalog# / Size 800708 / 50 µL
Clone
Regulatory Status RUO
Workshop HCDM listed
Other Names AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4,
protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral
vascular amyloid peptide, APP, Amyloid Precursor Protein
Previously Signet Catalog# 9200-02
Signet Catalog# 9200-05
Signet Catalog# 9200-10
Covance Catalog# SIG-39200
Isotype Mouse IgG2b, κ
Description Alzheimer’s disease is characterized by the accumulation of aggregated Aβ peptides in senile
plaques and vascular deposits. Aβ peptides are derived from amyloid precursor proteins (APP)
through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse
Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous
assemblies. Some forms of the aggregated peptides are toxic to neurons.
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文献和实验17-酮甾类(酮类固醇) 17-ketosteroid,17 oxosteroid
甾类骨架上第 17位碳原子上的氧基的化合物之总称,缩写 17KS。在生物体内,是由 17位羟基的酶促氧化和 C17 -C20 键切断生成的。在尿中含有来自副肾皮质的去氢表雄酮及其硫酸酯,睾丸酮的代谢物雄酮和表雄酮等。雌酮也以 17-酮甾类的形态存在着。因为副肾皮质和卵巢肿瘤患者的尿中的排出量很高,所以可作为临床的诊断指标。又因 17-酮甾类在碱性间 -硝基苯溶液中呈紫色,所以可进行定量测定。
Effects of the β-Amyloid Peptide on Membrane Ion Permeability
Several lines of evidence suggest a role for membrane ion channels in the neurotoxic effects of the β-amyloid peptide (Aβ). This chapter describes the electrophysiological techniques that can be employed to isolate and record specific membrane
C18 H24 O2 雌甾 -1, 3, 5( 10) -三烯 -3, 17-二醇。系代表性的性激素,可用卵巢、胎盘等制备,在卵泡液、胎盘、妊娠马尿中均可检出。进入子宫上皮细胞后,与性激素受体形成复合体进入细胞核,从而促进新的蛋白质合成,具有引起细胞增殖的作用。此外,能影响未成熟或切除卵巢的大鼠或小鼠的阴道分泌物,使呈现由角化细胞组成的显微镜象,所以也用作生物试验。在生物体内,在 17β -羟甾类脱氢酶的作用下氧化成为雌酮。 17α -羟甾体性激素的作用弱。作为女性
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