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- Solarbio
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- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥21120.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥14784.0 |
| 规格： | 50ug | 产品价格： | ￥3276.0 |
| 规格： | 10ug | 产品价格： | ￥1092.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | E3 Ubiquitin-Protein Ligase CHIP;Antigen NY-CO-7;CLL-Associated Antigen KW-8;Carboxy Terminus of Hsp70-Interacting Protein;STIP1 Homology and U Box-Containing Protein 1;STUB1;CHIP |
| 外观(性状) | Supplied as a 0.2 μm filtered solution of PBS, PH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 运输条件 | 干冰运输 |
| 背景说明 | E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein.CHIP is highly expressed in skeletal muscle，heart，pancreas，brain and placenta.CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome.CHIP targets misfolded chaperone substrates towards proteasomal degradation.CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome.It also may regulate the receptor stability and activity through proteasomal degradation. |
| 来源 | E.coli |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验Secretion of Recombinant Human Insulin-Like Growth Factor I (IGF-I)
The development of efficient recombinant protein production processes can be a critical factor in whether or not a pharmaceutical therapeutic protein can enter human clinical trials and ultimately the marketplace. This is especially true
浅析染色质免疫沉淀（ChIP）技术在 DNA 与蛋白质相互作用研究中的重要性
-19]； xChIP：用来研究DNA及低结合力蛋白，采用甲醛或紫外线进行 DNA 和蛋白交联，超声波片段化染色质，然后进行片段富集及后续分析，适用于多数非组蛋白的蛋白，例如 [9, 15, 20]。 X-ChIP 试验的一般过程 以上两种方法在分离 DNA-蛋白质复合物之后，对 DNA 进行 PCR 扩增，验证目标序列的存在。除验证实验外，ChIP DNA也可以进行测序分析，这种方法被称为 ChIP-seq [22] ；也可做芯片分析，这种方法被称为 ChIP on CHIP 或 ChIP
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