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- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Chloroquine
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
54-05-7
- 规格：
500mg/200mg/100mg/50mg
| 规格： | 500mg | 产品价格： | ￥1740.0 |
|---|---|---|---|
| 规格： | 200mg | 产品价格： | ￥866.0 |
| 规格： | 100mg | 产品价格： | ￥490.0 |
| 规格： | 50mg | 产品价格： | ￥340.0 |
是 autophagy 和 toll-like receptors (TLRs) 的抑制剂。据报道，还可以有效抑制 SARS-CoV-2 (COVID-19) 感染 。
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Baicalein Suppresses NLRP3 and AIM2 Inflammasome-Mediated Pyroptosis in Macrophages Infected by Mycobacterium tuberculosis via Induced Autophagy
成员:Bangzuo Ning; Jingjing Shen; Fanglin Liu; Hemin Zh
论文因子:9.043 发表期刊:Microbiology Spectrum pmid:37125940
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells
成员:Zhang L. Man S. Wang Y. Liu J. Liu Z. Yu P. Gao W.
论文因子:4.791 发表期刊:Chem Biol Interact pmid:27180204
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Increasing autophagy ameliorates all-trans-retinal-activated NLRP3 inflammasomes in human THP-1 macrophages
成员:Qingqing Xia; Jie Li; Lingmin Zhang; Yingying Zhou; Zaixing Yang; Jing Xie
论文因子:2.2 发表期刊:American Journal of Translational Research pmid:37434849
| 基本信息 | |
| CAS | No.54-05-7 |
| 中文名称 | 氯喹 |
| 英文名称 | Chloroquine |
| 别名 | Chloroquine free |
| 分子式 | C18H26ClN3 |
| 分子量 | 319.87 |
| 溶解性 | Soluble in DMSO/Ethanol ≥5mg/mL;Soluble in Water ≥1mg/mL(Need ultrasonic or Water bath) |
| 纯度 | ≥98% |
| 外观(性状) | White to yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-191-2 |
| MDL | MFCD00024009 |
| SMILES | CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl |
| InChIKey | WHTVZRBIWZFKQO-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21) |
| PubChem CID | 2719 |
| 靶点 | Autophagy, SARS-CoV, Toll-like Receptor (TLR) |
| 通路 | Autophagy;Anti-infection;Immunology/Inflammation |
| 背景说明 | Chloroquine是 autophagy 和 toll-like receptors (TLRs) 的抑制剂。据报道,还可以有效抑制 SARS-CoV-2 (COVID-19) 感染 。 |
| 生物活性 | Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1-4]. |
| In Vitro | Chloroquine(CHQ，20 μM)inhibits IL-12p70 release and reduces Th1-priming capacity of activated human monocyte-derived Langerhans-like cells(MoLC). Chloroquine(20 μM)enhances IL-1–induced IL-23 secretion in MoLC and subsequently increases IL-17A release by primed CD4+ T cells[1]. Chloroquine(25 μM)suppresses MMP-9 mRNA expression in normoxia and hypoxia in parental MDA-MB-231 cells. Chloroquine has cell-，dose- and hypoxia-dependent effects on MMP-2，MMP-9 and MMP-13 mRNA expression[2]. TLR7 and TLR9 inhibition using IRS-954 or chloroquine significantly reduces HuH7 cell proliferation in vitro[3].Chloroquine(0.01-100 μM; 48 hours)potently blocked virus infection(vero E6 cells infected with SARS-CoV-2)at low-micromolar concentration(EC50=1.13 μM). Chloroquine blocks virus infection by increasing endosomal pH required for virus/cell fusion，as well as interfering with the glycosylation of cellular receptors of SARS-CoV[4]. |
| 细胞实验 | TLR7 and TLR9 inhibition using IRS-954 or chloroquine significantly inhibits tumour growth in the mouse xenograft model. HCC development in the DEN/NMOR rat model is also significantly inhibited by Chloroquine[3].Chloroquine(80 mg/kg，i.p.)does not prevent the growth of the triple-negative MDA-MB-231 cells with high or low TLR9 expression levels in the orthotopic mouse model[2]. |
| 数据来源文献 | [1]. Said A， et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43. [2]. Tuomela J， et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672. [3]. Mohamed FE， et al. Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2014 Jul 2. doi: 10.1111/liv.12626. [4]. Colson P， et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020;55(4):105932. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Baicalein Suppresses NLRP3 and AIM2 Inflammasome-Mediated Pyroptosis in Macrophages Infected by Mycobacterium tuberculosis via Induced Autophagy
成员:Bangzuo Ning; Jingjing Shen; Fanglin Liu; Hemin Zh
论文因子:9.043 发表期刊:Microbiology Spectrum pmid:37125940
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells
成员:Zhang L. Man S. Wang Y. Liu J. Liu Z. Yu P. Gao W.
论文因子:4.791 发表期刊:Chem Biol Interact pmid:27180204
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Increasing autophagy ameliorates all-trans-retinal-activated NLRP3 inflammasomes in human THP-1 macrophages
成员:Qingqing Xia; Jie Li; Lingmin Zhang; Yingying Zhou; Zaixing Yang; Jing Xie
论文因子:2.2 发表期刊:American Journal of Translational Research pmid:37434849
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