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- 详细信息
- 文献和实验
- 技术资料
- 抗体名:
PE anti-human EGFR
- 抗体英文名:
PE anti-human EGFR
- 应用范围:
免疫荧光,流式
- 宿主:
小鼠
- 供应商:
上海善然生物
- 库存:
现货
- 抗原来源:
小鼠
- 保质期:
2-3年左右
- 适应物种:
人
- 标记物:
PE
- 克隆性:
单克隆
- 保存条件:
2-8度
- 形态:
液体
- 规格:
100 tests
PE anti-human EGFR Antibody
AY13
Catalog# / Size 352903 / 25 tests
352904 / 100 tests
Clone
Regulatory Status RUO
Other Names Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, HER1
Isotype Mouse IgG1, κ
Description Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and member of the
protein kinase superfamily that regulates cell growth and differentiation. EGFR binds EGF,
TGF-α, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30, and vaccinia
virus growth factor - all members of the EGF family. Ligand binding induces EGFR
dimerization and autophosphorylation, initiating the MAPK, Akt, and JNK signaling pathways.
EGFR is expressed by epithelial and endothelial cells and is frequently expressed by epithelial
carcinomas.
Product Details
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen Non-small cell lung cancer (NSCLC) cell line NCI-H322
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation The antibody was purified by affinity chromatography and conjugated with PE under optimal
conditions.
Concentration Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our
Certificate of Analysis online tool.)
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from
prolonged exposure to light. Do not freeze.
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T-cell dependent antigen specific in situ staining (Pe)
if you have them). Let them dry approx 1 hour in a dry atmosphere at RT. Antibodies (anti-Pe) in the sections degrade more rapidly than tissue antigens. Proceed with staining within 24 hours or freeze the slides. Antigen-specific staining: (Pe staining of Pe
EGFR and Tumor Suppressor Function in Brain Cancer Development
of a conditional firefly luciferase transgene provides a means to monitor tumor initiation and growth noninvasively by bioluminescence imaging. The tumors that are generated in this model share numerous histopathological features with human GBMs. We provide
The EGFR Pathway as an Example for Genotype: Phenotype Correlation in Tumor Genes
to be determinants of response to new drugs that inhibit EGFR. We describe the correlation between the EGFR genotype, including the KRAS mutation, and the consequences of the resulting genotype for anti-EGFR therapy in colorectal cancer.
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