Brilliant Violet 711™ anti-hum

Brilliant Violet 711™ anti-human TNF-α Antibody
MAb11
Catalog# / Size 502939 / 25 tests
502940 / 100 tests
Clone
Regulatory Status RUO
Other Names Tumor necrosis factor-α, Cachectin, Necrosin, Macrophage cytotoxic factor (MCF), Differentiation
inducing factor (DIF), TNFSF2
Isotype Mouse IgG1, κ
Description TNF-α is secreted by macrophages, monocytes, neutrophils, T cells, and NK cells. Many
transformed cell lines also secrete TNF-α. Monomeric human TNF-α is a 157 amino acid protein
(non-glycosylated) with a reported molecular weight of 17 kD. TNF-α forms multimeric complexes;
stable trimers are most common in solution. A 26 kD membrane form of TNF-α has also been
described. TNF-α binding to surface receptors elicits a wide array of biological activities including:
cytolysis and cytostasis of many tumor cell lines in vitro, hemorraghic necrosis of tumors in vivo,
increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.
Product Details
Verified Reactivity Human
Reported Reactivity Cat, Chimpanzee, Baboon, Cynomolgus, Rhesus, Pigtailed Macaque, Sooty Mangabey, Pig
Antibody Type Monoclonal
Host Species Mouse
Immunogen E. coli-expressed, recombinant human TNF-α
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 711™ under
optimal conditions.
Concentration Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our
Certificate of Analysis online tool.)
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged
exposure to light. Do not freeze