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- 详细信息
- 文献和实验
- 技术资料
- 库存:
100
- 供应商:
艾美捷科技
- 英文名:
ADCP Bioassay Effector Cell FcγRIIa (H variant) /NFAT Reporter-Jurkat
- 规格:
2 vials
ADCP 生物测定效应细胞 FcγRIIa (H 变体) /NFAT 报告基因-Jurkat,ADCP Bioassay Effector Cell FcγRIIa (H variant) /NFAT Reporter-Jurkat ,ADCP 生物测定效应细胞 FcγRIIa (H 变体) /NFAT 报告基因-Jurkat,ADCP Bioassay Effector Cell FcγRIIa (H variant) /NFAT Reporter-Jurkat
ADCP 生物测定效应细胞 FcγRIIa (H 变体) /NFAT 报告基因-Jurkat-ADCP Bioassay Effector Cell FcγRIIa (H variant) /NFAT Reporter-Jurkat
产品货号:BPS-71273
产品规格:2 vials

抗体依赖性细胞介导的吞噬作用是抗体药物开发的重要作用机制之一。FcγRIIa是参与ADCP过程的主要Fcγ受体。FcγRIIa在骨髓效应细胞(包括巨噬细胞和嗜中性粒细胞)中表达,其在这些效应细胞的活化中起作用。几项临床研究已经研究了FcγRIIa多态性(R131H)与对igg1亚类单克隆抗体(mab)如利妥昔单抗的反应的相关性。已经开发了fc-mab中的工程化氨基酸取代以增强巨噬细胞对mab介导的肿瘤细胞的吞噬作用。

表征抗体的Fc效应功能。

ADCP 生物测定效应细胞 FcγRIIa (H 变体) /NFAT 报告基因-Jurkat-ADCP Bioassay Effector Cell FcγRIIa (H variant) /NFAT Reporter-Jurkat 收到后立即储存在液氮中。
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