DNMT1-IN-3,3025012-68-1

DNMT1-IN-3 产品活性：DNMT1-IN-3 (compound 7t-S) 是一种强效的 DNA 甲基转移酶 1 (DNMT1) 抑制剂，IC50 值为 0.777 μM，KD 值为 0.183 μM。DNMT1-IN-3 可与 DNMT1 中的 S - 腺苷甲硫氨酸 (SAM) 位点结合。DNMT1-IN-3 可通过诱导细胞凋亡和引起细胞 G0 / G1 期阻滞来抑制 K562 细胞的增殖，有潜力用于血液肿瘤的研究。 产品来源： www.medchemexpress.cn/dnmt1-in-3.html 研究领域：Epigenetics 作用靶点：DNA Methyltransferase In Vitro: DNMT1-IN-3 (compound 7t-S) (0-400 μM; 48 h) demonstrates potential anti-proliferative activity on various tumor cell lines including A2780, HeLa, K562, and SiHa. DNMT1-IN-3 (20-60 μM; 48 h) can arrest K562 cells in the G0 / G1 phase in a concentration-dependent manner, as determined by flow cytometry assays. DNMT1-IN-3 (43.89 μM) can induce apoptosis in K562 cells by upregulating the expression of apoptosis-related genes suppressed by methylation, such as death receptor TRAIL-R2/Dr5 and TNFR-1. TRAIL-R2 can instigate the cell apoptosis signal by recruiting Caspase-8 or Caspase-10 to initiate downstream Caspase cascade reactions. 。 相关产品：Decitabine | 5-Azacytidine | GSK-3484862 | GSK-3685032 | RG108 | SGI-1027 | 6-Thioguanine | Bobcat339 hydrochloride | Hinokitiol | Zebularine | CM-272 | 5-Fluoro-2'-deoxycytidine | DNMT3A-IN-1 | Procainamide | γ-Oryzanol | Guadecitabine sodium | Levetiracetam | DY-46-2 | 5-Methyl-2'-deoxycytidine | Lomeguatrib | TFMB-(S)-2-HG | CM-579 trihydrochloride | DC_517 | GSK3735967 | METTL1-WDR4-IN-2 | Psammaplin A | DC-05 | Benzyl selenocyanate 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。