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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
零下80~20°C
- 保质期:
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名:
TRPC6-IN-3
- 库存:
10
- 供应商:
TargetMol
- CAS号:
2311863-36-0
- 规格:
2 mg/25 mg/50 mg/100 mg
| 规格: | 2 mg | 产品价格: | ¥3930.0 |
|---|---|---|---|
| 规格: | 25 mg | 产品价格: | ¥10500.0 |
| 规格: | 50 mg | 产品价格: | ¥13700.0 |
| 规格: | 100 mg | 产品价格: | ¥17400.0 |
Product Introduction
Bioactivity
英文名:TRPC6-IN-3
描述:TRPC6-IN-3 (compound 17) is an orally active inhibitor of the transient receptor potential C6 ion channel (TRPC6), which regulates intracellular calcium concentration and also regulates cation fluxes including calcium and sodium ions to modulate membrane potential.

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文献和实验Neuron:北大陈雷研究组报道胞内钙离子对 TRPC3/6 通道调控的机制
经典型瞬时受体电势通道 TRPC 是一类通透钙离子的非选择性阳离子通道1,与最早在果蝇感光系统中发现的 TRP 通道的序列相似性最高2,3,并且可以被第二信使 DAG 所激活。根据序列相似性以及通道的电生理特性,TRPC3/6/7 形成了一个亚类4。 TRPC3/6/7 通道参与多种神经活动,例如 TRPC3 在中枢神经系统高表达,参与神经生长因子 BDNF 信号转导5,同时 TRPC3 还与神经突触信号传递以及运动协调有关6,7。TRPC6 通道可以促进神经元存活以及兴奋性突触的形成
Single-Channel Analysis of TRPC Channels in the Podocytes of Freshly Isolated Glomeruli
basement membrane turnover. Dysfunction of podocytes is a major cause of glomerular kidney diseases. Gain-of-function mutations in the TRPC6 channel underlie a subset of familial forms of focal segmental glomerulosclerosis (FSGS). While growing evidence
Measurement and Manipulation of Intracellular Ca2+ in Single Platelets and Megakaryocytes
-dependent Ca2+ influx also seems to exist in the platelet (9 ) and TRPC6, a nonselective cation channel known to be activated by the PLC product diacylglycerol (DAG), has recently been detected in platelets and megakaryocytic cell lines (10 ). Finally
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