Lapatinib 拉帕替尼

【共享】中山大学Nature发文构建RNA干扰肿瘤新平台

称为HER2的蛋白，这类乳腺癌通常具有高度侵袭性。随着诸如曲妥珠单抗（trastuzumab ，商品名为Herceptin®）和拉帕替尼（lapatinib ，商品名为Tykerb®）一类的靶向性药物出现，它们也开始取得了良好的治疗效果。然而那些耐受曲妥珠单抗、复发性的，或不表达HER2的乳腺癌目前却仍然难于治疗。为了开发出乳腺癌的其他靶向性治疗策略，Lieberman与宋尔卫将研究焦点转向了一种称为RNA干扰 (RNAi) 的分子现象。RNAi是指通过小干扰RNAs(siRNAs)这类小片

ERBB4 Mutation Analysis: Emerging Molecular Target for Melanoma Treatment

to small-molecule inhibition with the dual-tyrosine kinase inhibitor lapatinib, and has recently also been implied in oncogenic glutamatergic signaling in melanoma. Mutations involving the ERBB4 gene act as “gain-of-function” mutations and predominantly