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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
peptide
- 亚型:
IgG1
- 形态:
Liquid
- 保存条件:
-20℃
- 克隆性:
mAb
- 适应物种:
Human
- 保质期:
1年
- 目录编号:
TD-31619
- 级别:
科研级
- 库存:
88
- 供应商:
武汉天德
- 宿主:
Mouse
- 应用范围:
FCM、ELISA
- 靶点:
详询
- 抗体英文名:
Mouse Monoclonal Antibody to CD27
- 抗体名:
CD27
- 规格:
100ul/50ul
| 规格: | 100ul | 产品价格: | ¥2180.0 |
|---|---|---|---|
| 规格: | 50ul | 产品价格: | ¥1280.0 |
Mouse Monoclonal Antibody to CD27
Description |
|
| The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. | |
Specification |
|
| Aliases | T14; S152; Tp55; TNFRSF7; S152. LPFS2 |
| Entrez GeneID | 939 |
| Swissprot | P26842 |
| clone | 3B6D3 |
| WB Predicted band size | 29.1kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD27 (AA: extra 20-144) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
|
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
Product Image |
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文献和实验CD27 分子 CD27 常用单克隆抗体或代号: VIT14,S152,OKT18A 主要表达细胞: T, Bsub [T] 分子质量(kDa)和结构: p55(TNFR- SF)(同源二聚体) 功 能: CD70的配体,T细胞活化增殖 CD27 Marker of T cell activation CD27/CD70 interactions also regulate
Nature Medicine 再论多重免疫荧光揭示预测性生物标志物,用于优化免疫治疗临床试验设计
,这可以独立于 CD8+ T 细胞浸润水平来预测存活率。 使用转录组测序技术分析 TLS 阳性肉瘤对派姆单抗反应的决定因素 使用多重免疫荧光 (mIF) 分析显示,这类“高免疫”肉瘤的特征在于存在肿瘤内 TLSs. 三级淋巴结构(TLS)是 B 细胞滤泡、滤泡树突细胞 (DC) 和 CD4+ 和 CD8+ T 细胞的异位形成的聚集体,多项研究已证明其和抗癌免疫高度相关。 多重免疫荧光标记MUM1/CD20/CD27/CD3/COL1A1/IgG、CD8/GzmA/CD4/FOXP3/CD56分析TLS
性T细胞表型的异同点。可以看出,第一,所有的记忆性T细胞(CD4TCM、CD4TEM、CD8TCM和CD8TEM)皆为CD45RO+,但CD8TCM中有一个亚群为CD45RO-CD45RA+,特称为CD8TEMRA。第二,对CCR7和CD62L这两种表面分子,只有TCM为阳性,而TEM为阴性,这也是表9―5所展示的情况。CD27和CD28的表达格局比较复杂,虽主要于表达在TCM,但也有例外。至于其他一些标志的表达格局,则因细胞亚群的不同而呈现变化。 人体记忆
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