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- BioGems
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- 2025年07月11日
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- 详细信息
- 技术资料
- 克隆性：
C17.8
- 标记物：
PE
- 规格：
100 μg
Anti-Mouse IL-12/IL-23 p40 PE 同型对照:Rat IgG2a, kappa标记:PE
IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-γ production
by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and
connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth
and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-γ-
producing Th1 cells.
IL-23 is a proinflammatory, heterodimeric protein composed of two subunits: a unique p19
subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic
cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-
12Rβ2. IL-23 has been shown to enhance proliferation of memory T cells. It also stimulates the
production of IFN-γ in NK cells, induces IL-17 production, and drives Th17-mediated responses.
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Anti-Mouse IL-12/IL-23 p40 PE (100 μg)
￥3628
