- ￥4260
- 南京万木春生物
- 进口/国产
- WM-24JY584
- 2025年12月13日
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- 英文名：
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- 库存：
现货库存
- 供应商：
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- 肿瘤类型：
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- 细胞类型：
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- 品系：
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- 组织来源：
ATCC/DSMZ/ECACC
- 相关疾病：
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- 物种来源：
人或动物
- 免疫类型：
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- 细胞形态：
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- 是否是肿瘤细胞：
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- 器官来源：
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- 运输方式：
常温或干冰
- 年限：
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- 生长状态：
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- 规格：
T25
| 种属 | 小鼠 |
| 组织来源 | 正常肝组织 |
| 传代比例 | 1:2传代 |
| 完全培养基配置 | 基础培养基500ml ；生长添加剂5ml ；胎牛血清50ml ；双抗5ml |
| 简介 | 肝星状细胞（ HSC)位于Disse间隙内 ，紧贴着肝窦内皮细胞和肝细胞。其形态不规则 ，胞体呈圆形或不规则形 ，常伸 出数个星状胞突包绕着肝血窦。此外 ，HSC还伸出胞突与肝细胞、邻近的星状细胞相接触。HSC是ECM的主要来源 ， HSC激活并转化为肌成纤维细胞样细胞(MFC) ，各种致纤维化因素均把HSC作为最终靶细胞。肝星状细胞激活并转化 为肌成纤维细胞样细胞(MFC) ，各种致纤维化因素均把HSC作为最终靶细胞 ，正常情况下肝星状细胞处于静止状态。 当肝脏受到炎症或机械刺激等损伤时 ，肝星状细胞被激活 ，其表型由静止型转变为激活型。激活的肝星状细胞一方面 通过增生和分泌细胞外基质参与肝纤维化的形成和肝内结构的重建 ，另一方面通过细胞收缩使肝窦内压升高。 |
Genomes (KEGG) pathway enrichment analysis. The copy number variations (CNVs), single nucleotide polymorphisms (SNPs) and tumor mutation burden were analyzed using Gistic 2.0, R package maftools, and TCGA mutations, respectively. Estimation of STromal and Immune cells in biostatisticians, and representatives from industry and government to develop Trial Reporting in Immuno-Oncology (TRIO) recommendations. These recommendations are based on expert consensus, given that existing data to support evidence-based recommendations are limited.
Cancer cells in the bone metastasis would acquire their characteristic malignant potentials by breaking through the struggle for existence in the various metastasis steps, all of which are required for the cancer cells in the bone microenvironment to emerge as clinical bone metastasis. We have demonstrated that receptor activator of NF-κB ligand (RANKL) was involved in the tumor-stromal interaction in the bone microenvironment and TGFβ stored in the bone matrix was released with the bone destruction, which promoted the proliferation of cancer cells in the bone. We also demonstrated that epigenetics, which is the transcriptional regulatory mechanism without gene mutation, was involved in the acquisition of drug resistance in the cancer cells. We believe that the mechanisms for bone metastasis formation would be fully elucidated in the near future, and the molecular-targeted therapies, which was developed based on these findings, would relief the patients from the fear of death.
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文献和实验/nearest template prediction algorithms were used to perform molecular clustering. The biological functions of differentially expressed genes (DEGs) were identified using Metascape, gene set enrichment analysis (GSEA), gene ontology (GO) and the Kyoto Encyclopedia of Genes and
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