MOILANEN LJ,HÄMÄLÄINEN M,ILMARINEN P, et al.Transientreceptorpotential ankyrin1 enhances ovalbumin-inducedacuteallergicinflammationinmurine models[J]. IntArchAllergyImmunol,Description: This main goal of this article is to summarize and highlight main challenges of early-phase study design of immunotherapies from a statistical perspective. We compared the underlying toxicity and ewdtcacy assumptions of cytotoxic versus immune-oncology agents, proposed novel endpoints to be included in the dose-selection process, and reviewed design