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- 2025年07月11日
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- 保存条件：
RT/2-8℃/-20℃
- 保质期：
3年
- 英文名：
Novobiocin Sodium Salt
- 库存：
999
- 供应商：
北京康瑞纳生物科技有限公司
- CAS号：
1476-53-5
- 规格：
250mg
新生霉素 1476-53-5 新生霉素 1476-53-5
产品名称：新生霉素 1476-53-5
产品编号：A2550
英文别称 Novobiocin sodium salt
CAS 1476-53-5
分子式 C31H35N2NaO11
分子量 634.61
储存条件 2-8℃
有效期 4年
酶活/效价 > 850 micrograms/mg
包装 瓶
规格 250mg
说明：通过抑制细胞增殖、抑制DNA合成、影响拓扑异构酶ⅡDNA交联复合物的形成及延误细胞周期进展发挥抗癌作用。
新生霉素是一种分离自雪白链霉菌（Streptomyces niveus）的氨基香豆素类抗生素，也称为Streptonivicin，是一种强效的细菌DNA促旋酶（DNA gyrase）和真核DNA拓扑异构酶II的抑制剂。其抗菌谱为革兰氏阳性菌，作用机制是特异性靶向参与能量转移的GyrB亚基活性，进而干扰DNA合成并最终影响细菌生长。类似于其他氨基香豆素类抗生素如氯新生霉素（clorobiocin）和香豆霉素A1（coumermycin A1），它能够竞争性抑制GyrB催化发生的ATPase酶反应。对逆转录酶RNA依赖的DNA聚合酶具有抑制作用。另外还是热休克蛋白90（Hsp90）的抑制剂，特异性结合Hsp90的C末端ATP结构域，影响同源二聚体的形成。
溶解度（供参考）： Soluble in water (100 mg/ml), ethanol, DMSO, alcohol (1:7), and methanol (1:3).易溶于水，适用于制备正超螺旋质粒DNA，也可用来研究细胞内Hsp90的抑制功能。
其最小抑菌浓度（MIC）为0.1~10 µg/ml。
Neomycin 1476-53-5
Product name: Neomycin 1476-53-5
Product number: A2550
English alias Novobiocin sodium salt
CAS 1476-53-5
Molecular formula C31H35N2NaO11
Molecular weight 634.61
Storage conditions 2-8 ℃
Valid for 4 years
Enzyme activity/potency>850 micrograms/mg
Packaging bottle
Specification 250mg
Explanation: It exerts anticancer effects by inhibiting cell proliferation, inhibiting DNA synthesis, affecting the formation of topoisomerase II DNA cross-linking complexes, and delaying cell cycle progression.
Neomycin is an aminocoumarin antibiotic isolated from Streptomyces niveaus, also known as Streptonivicin, which is a potent inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase II. Its antibacterial spectrum is Gram positive bacteria, and its mechanism of action is to specifically target the activity of GyrB subunits involved in energy transfer, thereby interfering with DNA synthesis and ultimately affecting bacterial growth. Similar to other amino coumarin antibiotics such as clorobiocin and coumarin A1, it can competitively inhibit the ATPase enzyme reaction catalyzed by GyrB. It has an inhibitory effect on reverse transcriptase RNA dependent DNA polymerase. Additionally, it is an inhibitor of heat shock protein 90 (Hsp90) that specifically binds to the C-terminal ATP domain of Hsp90 and affects the formation of homologous dimers.
Solubility (for reference): Soluble in water (100 mg/ml), ethanol, DMSO, alcohol (1:7), and methanol (1:3). Easy to dissolve in water, suitable for preparing positive supercoiled plasmid DNA, and also for studying the inhibitory function of Hsp90 in cells.
Its minimum inhibitory concentration (MIC) is 0.1-10 µ g/m
溶解性:DMSO，鉴定方法:液相，熔点:102℃-260℃，沸点：522.2°C at 760 mmHg，密度:1.064 g/cm³，保存条件:-20℃/2-8℃/RT避光，运输条件:2-8℃，保质期:2年，产地:国产/进口，品牌:北京康瑞纳生物，类别:生化试剂，库存:999，用途:用于科研实验，细胞培养，体外诊断，配方原料，医药生产等方面；使用方法: 详询客服
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文献和实验Ren L, Liu J, Liu C, Yang T, Wu X, Zhang X, Yang L, Xia J, Li W. AIn Vitro Cell（RAW264.7 cells；100 ng/mL LPS，24 h at 37 °C） RAW264.7 cells were seeded in confocal dishes at a density of 1 × 105 cells per dish. After the culture of 24 h, cells were treated with 100 ng/mL LPS in different media, including a control medium, PACDFe extract, and PACDFe hydrogel extract supplemented with 1 μM LL-37 for another 24 h at 1084 °C. 更多文献信息请详询客服
