- ￥441 - 2800
- MedChemExpress(MCE)
- 美国
- HY-B0425A
- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
Albamycin sodium; Cathomycin sodium
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1476-53-5
- 规格：
25 mg/50 mg/100 mg/500 mg/1 g
| 规格： | 25 mg | 产品价格： | ￥441.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥621.0 |
| 规格： | 100 mg | 产品价格： | ￥900.0 |
| 规格： | 500 mg | 产品价格： | ￥2000.0 |
| 规格： | 1 g | 产品价格： | ￥2800.0 |
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Novobiocin sodium
CAS No. : 1476-53-5
MCE 国际站：Novobiocin sodium
产品活性：Novobiocin (Albamycin) sodium 是一种有效且具有口服活性的抗生素。Novobiocin sodium 还是 DNA 促旋酶抑制剂和热休克蛋白 90 (Hsp90) 拮抗剂。Novobiocin sodium 具有研究高度耐药性肺炎球菌感染的潜力。Novobiocin Sodium 具有抗正痘病毒活性。
研究领域：Anti-infection | Apoptosis | Cell Cycle/DNA Damage | Metabolic Enzyme/Protease
作用靶点：Bacterial | Antibiotic | Orthopoxvirus | Apoptosis | DNA/RNA Synthesis | HSP
In Vitro: Novobiocin sodium (1 mM) competitively inhibits ATP binding to gyrase B to interfere with nucleotide binding and interferes with the association of the co-chaperones Hsc70 and p23 with Hsp90.
Novobiocin sodium (200 µM; 24 h) inhibits the rate of repair of both cis-DDP and BCNU induced DNA interstrand cross-links and with a corresponding decrease in the clonogenic survival of the human glioblastoma multiforme cells.
Novobiocin sodium (0.3 mM; 48 hours) induces a caspase-3/7 enzyme–dependent apoptosis assays with an induction of approximately three- to fivefold of apoptotic cells in K562, HL60, Mutz-2.
In Vivo: Novobiocin sodium (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24 and 48 h after infection) shows anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.
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|Northwestern印迹（法），RNA-蛋白质印迹（法） norvaline|正缬氨酸 norwalk virus|诺沃克病毒[可引起腹泻，属杯状病毒科] notatin|葡糖氧化酶 notexin|虎蛇毒素，黑牙蛇毒素 notocord|脊索 novobiocin|新生霉素 nuclear envelope|核被膜，核包膜 nuclear reticulum|核网
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