Ultra-LEAF™ Purified 抗人 CD314

Ultra-LEAF™ Purified anti-human CD314 (NKG2D) Antibody详细如下：

Description ：CD314 is a homodimeric C-type lectin-like protein also known as NKG2D. It is expressed on NKcells, CD8 T cells, γ/δ T cells, and in vitro induced LAK cells. Several molecules have beenidentified as the ligands for NKG2D, including MHC class-I chain-related protein A (MICA),MICB, and UL16-binding proteins (ULBPs). NKG2D has no intrinsic signaling capacity, butattains this by non-covalent association with DAP10 or DAP12 adaptors. In addition to being aprimary activation receptor on NK cells, NKG2D is also a costimulatory receptor for TCRmediated T cell proliferation and cytokine production. The interaction of NKG2D with its ligandsplays a role in the immune surveillance against pathogen and tumor cells, and in thepathogenesis of autoimmune diseases.

Verified Reactivity ：Human

Reported Reactivity ：African Green, Baboon, Cynomolgus, Rhesus

Antibody Type ：Monoclonal

Host Species ：Mouse

Formulation ：0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxinlevel is <0.01 EU/µg of the protein (<0.001 ng/µg of the protein) as determined by the LAL test.

Preparation ：The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.

Concentration ：The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentrationand expiration, please enter the lot number in our Certificate of Analysis online tool.

Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™solution contains no preservative; handle under aseptic conditions.

Application ：FC - Quality tested、IP, FA - Reported in the literature, not verified in house

Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cellsin 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated foroptimal performance for each application.