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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
Ly-49C/F/I/H
- 级别：
Ly-49C/F/I/H Antibody
- 目录编号：
Ly-49C/F/I/H Antibody
- 克隆性：
单克隆
- 抗原来源：
仓鼠
- 保质期：
Ly-49C/F/I/H Antibody
- 抗体英文名：
Purified anti-mouse Ly-49C/F/I/H Antibody
- 抗体名：
Ly-49C/F/I/H Antibody
- 标记物：
Ly-49C/F/I/H Antibody
- 宿主：
仓鼠
- 适应物种：
小鼠
- 免疫原：
Ly-49C/F/I/H Antibody
- 亚型：
Ly-49C/F/I/H Antibody
- 形态：
Ly-49C/F/I/H Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
0.5 mg/ml
- 规格：
500 µg
Description ：The 14B11 antibody reacts with a common epitope of Ly-49C/F/I/H family members also knownas Ly-49 inhibitory receptors C, F, and I and activating receptor H. It does not react with otherLy-49 members (i.e., Ly-49A, B, D, and G). Ly-49 is a type-II transmembrane, disulfide-linkedhomodimer with C-type lectin extracellular domains that binds to MHC class I. Ly-49C/F/I/H isexpressed on a subset of NK cells, NK-T cells and some CD8 cells. Ly-49C/F/I, like othermembers of this family, inhibits NK cell activation through the recognition and interaction ofcertain MHC class I haplotypes on potential target cells. Ly-49C, Ly-49F, and Ly-49I contain anITIM motif in their cytoplasmic tails, while Ly-49H lacks ITIM. Ly-49H is encoded by the Cmv1rgene, which promotes resistance to infection by mouse cytomegalovirus (CMV). BALB/c miceare reported to lack the Ly-49H and Ly-49I receptors. The 14B11 antibody, when bound to NKcells, is capable of inducing redirected cell lysis and blocking NK cell effector function.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Syrian Hamster
Immunogen ：IL-2-activated killer cells (LAK) from C57BL/6 mice
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
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文献和实验1. Corral L, et al. 1999. Hybridoma 18:359.
2. Hanke T, et al. 1999. Immunity 11:67.
Product Citations：
1. Brownlie D, et al. 2021. J Immunother Cancer. 9:. PubMed
a look from the following website just by clicking "Tyrosine Phosphorylation and Dimerization" http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSN-43F85YV-2&_user=1111158&_coverDate=06%2F29%2F2001&_rdoc=1&_fmt=full&_orig=search
流式抗体的选择和配色原则由于在流式细胞实验过程中，荧光抗体对单细胞悬液的标记效果直接影响实验的数据质量。因此，需要考虑各种影响流式抗体品质及检测效果的因素，例如抗体特异性、荧光素信号强弱、荧光素标记方式、同型对照等。本文介绍如何选择合适的流式抗体： 1、需要满足抗体选择的最基本条件：目标蛋白特异性，反应种属以及应用实验等。 靶标特异性：确定标记物名称，确定是细胞表面表达，还是细胞内表达。细胞内表达需要进行透膜。 物种来源：确定待测样本的种属来源。例如，抗小鼠的抗体，不能用于人的样本的检测
出现IgG 分子50 and 25 kDa 的重链和轻链条带。 5 二抗的选择 二抗应选用与使用的一抗相同的物种来源，例如：如果你的一抗是小鼠的单克隆抗体，二抗则选抗小鼠的二抗anti-mouse secondary。建议检查二抗说明书确保该抗体适用于你的检测应用， 二抗一般连接荧光素FITC 或发光团。 6 双重染色抗体的选择用未偶联一抗进行细胞培养物或组织切片的双重免疫染色要求一抗来源于不同物种并且二抗分别识别其中之一，二抗说明书应描述其与其它物种来源的免疫球蛋有否有交叉吸附。 想了解
