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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CD223
- 级别：
CD223 (LAG-3) Antibody
- 目录编号：
CD223 (LAG-3) Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
CD223 (LAG-3) Antibody
- 抗体英文名：
Alexa Fluor® 647 anti-human CD223 (LAG-3) Antibody
- 抗体名：
CD223 (LAG-3) 抗体
- 标记物：
CD223 (LAG-3) Antibody
- 宿主：
小鼠
- 适应物种：
人
- 免疫原：
CD223 (LAG-3) Antibody
- 亚型：
CD223 (LAG-3) Antibody
- 形态：
CD223 (LAG-3) Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
CD223 (LAG-3) Antibody
- 规格：
25 tests/100 tests
| 规格： | 25 tests | 产品价格： | ￥2800.0 |
|---|---|---|---|
| 规格： | 100 tests | 产品价格： | ￥6800.0 |
Description ：CD223, also known as LAG-3, is a 70 kD type I transmembrane glycoprotein that is involved inT-cell signaling. Similar to CD4, CD223 binds MHC class II, but with a higher affinity. CD223negatively regulates T-cell activation. It is expressed by activated T-cells and natural killer cells(NKs), as well as regulatory T-cells. It is transiently expressed on the surface of activated Tcells in acute conditions but high expression is maintained under tolerizing conditions. CD223deficiency results in reduced tumor growth. CD223 and PD-1 can act in synergy and reverseexhausted phenotypes, improve tumor rejection, and control viral load.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Human LAG-3 transfected cells.
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation ：The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647under optimal conditions.
Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
Excitation Laser ：Red Laser (633 nm)
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文献和实验1. Acharya N, et al. 2020. Immunity. 53(3):658-671.e6. PubMed
2. Halim L, et al. 2022. Front Immunol. 13:836549. PubMed
3. Beatson RE, et al. 2021. Cell Rep Med. 2:100473. PubMed
4. Wilson TL, et al. 2022. Cancer Discov. 12:2098. PubMed
5. Franchini DM et al. 2019. Cell reports. 26(1):94-107 . PubMed
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种类型的荧光抗体在单个标本中准确展示荧光标记分子的共定位情况。 PLAPON60XOSC 和 UPLSAPO60XO 的性能比较 2. 超级色差校正物镜的应用-脑组织的四重免疫荧光 图 1. 脑组织的四重免疫荧光。 VIAAT 染色（Alexa Fluor405，蓝色）；CB1 染色（Alexa Fluor488，绿色）；VGluT3 染色（Cy3，红色）；DGLα染色（Alexa Fluor647，白色）。 大麻素合成酶 DGLα（白色）和大麻素受体 CB1（绿色）聚集在小鼠
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