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- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CD223
- 级别：
CD223 (LAG-3) Antibody
- 目录编号：
CD223 (LAG-3) Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
CD223 (LAG-3) Antibody
- 抗体英文名：
Alexa Fluor® 700 anti-human CD223 (LAG-3) Antibody
- 抗体名：
CD223 (LAG-3) 抗体
- 标记物：
CD223 (LAG-3) Antibody
- 宿主：
小鼠
- 适应物种：
人
- 免疫原：
CD223 (LAG-3) Antibody
- 亚型：
CD223 (LAG-3) Antibody
- 形态：
CD223 (LAG-3) Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
CD223 (LAG-3) Antibody
- 规格：
25 tests/100 tests
| 规格： | 25 tests | 产品价格： | ￥3200.0 |
|---|---|---|---|
| 规格： | 100 tests | 产品价格： | ￥7400.0 |
Description ：CD223, also known as LAG-3, is a 70 kD type I transmembrane glycoprotein that is involved inT-cell signaling. Similar to CD4, CD223 binds MHC class II, but with a higher affinity. CD223negatively regulates T-cell activation. It is expressed by activated T-cells and natural killer cells(NKs), as well as regulatory T-cells. It is transiently expressed on the surface of activated Tcells in acute conditions but high expression is maintained under tolerizing conditions. CD223deficiency results in reduced tumor growth. CD223 and PD-1 can act in synergy and reverseexhausted phenotypes, improve tumor rejection, and control viral load.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Human LAG-3 transfected cells.
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation ：The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 700under optimal conditions.
Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent betitrated for optimal performance for each application.
* Alexa Fluor® 700 has a maximum emission of 719 nm when it is excited at 633 nm / 635 nm. Priorto using Alexa Fluor® 700 conjugate for flow cytometric analysis, please verify your flowcytometer's capability of exciting and detecting the fluorochrome.
Excitation Laser ：Red Laser (633 nm)
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