Cyanine7 抗小鼠 CD274（B7-H1，PD-L1

Description ：CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type Itransmembrane protein and a member of the B7 family within the immunoglobulin receptorsuperfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activatedendothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1with PD-1 plays an important role in the inhibition of T cell responses. Other studies haveshown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 isinvolved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, inan IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cellproliferation and cytokine production.

Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Rat
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 underoptimal conditions.
Concentration ：0.2 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.

Application ：FC - Quality tested

Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.

Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)

Additional Product Notes ：BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye moleculeremains the same, so you should expect the same quality and performance from ourPE/Cyanine7 products. Please contact Technical Service if you have any questions.