PD-L1 / B7-H1 / CD274抗体

PD-L1 / B7-H1 / CD274抗体产品信息
免疫原 : Recombinant Mouse PD-L1 / B7-H1 / CD274 protein (Catalog#50010-M08H)
Reagents : PE-conjugated rabbit monoclonal antibody
Clone ID : 485
抗体宿主 : Rabbit IgG
Concentration : 2 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PD-L1 / B7-H1 / CD274 (rM PD-L1 / B7-H1 / CD274; Catalog#50010-M08H; NP_068693.1; Met1-Thr238) and conjugated with PE under optimum conditions, the unreacted PE was removed.
PD-L1 / B7-H1 / CD274抗体 Background
B7 homolog 1 (B7-H1), also called programmed death ligand 1 (PD-L1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between B7-H1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. As a costimulator, B7-H1 induces T-cell proliferation and preferentially the production of interleukin 10 and interferon gamma. Conversely, by binding to programmed death 1 receptors (PD-1) on activated T-cells and B-cells, B7-H1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, B7-H1 leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. B7-H1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
PD-L1 / B7-H1 / CD274抗体相关产品如下：xy-0296xy-Axyxy Mouse IgG/APC荧光素APC标记小鼠IgG(细胞流式同型对照)
xy-0293xy-Axyxy Rat IgG/APC荧光素APC标记大鼠IgG(细胞流式同型对照)
xy-0326xy-Axyxy Bovine IgG/APC荧光素APC标记牛IgG
xy-0327xy-Axyxy Bovine IgM/APC荧光素APC标记牛IgM
xy-0310xy-Axyxy Chicken IgG/APC荧光素APC标记鸡IgG
xy-0314xy-Axyxy Chicken IgM/APC荧光素APC标记鸡IgM
xy-0303xy-Axyxy dog IgG/APC荧光素APC标记狗IgG
xy-0373xy-Axyxy dog IgM/APC荧光素APC标记狗IgM
xy-0370xy-Axyxy Goat IgM/APC荧光素APC标记羊IgM
xy-0358xy-Axyxy Guinea IgG/APC荧光素APC标记豚鼠IgG
xy-0375xy-Axyxy Guinea IgM/APC荧光素APC标记豚鼠IgM
xy-0308xy-Axyxy Horse IgG/APC荧光素APC标记马IgG
xy-0374xy-Axyxy Horse IgM/APC荧光素APC标记马IgM
xy-0297xy-Axyxy human IgG/APC荧光素APC标记人IgG
xy-0345xy-Axyxy human IgM/APC荧光素APC标记人IgM
xy-0360xy-Axyxy human IgA/APC荧光素APC标记人IgA
xy-0335xy-Axyxy Monkey IgG/APC荧光素APC标记猴IgG
xy-0336xy-Axyxy Monkey IgM/APC荧光素APC标记猴IgM
xy-0309xy-Axyxy pig IgG/APC荧光素APC标记猪IgG
xy-0346xy-Axyxy Rat IgM/APC荧光素APC标记大鼠IgM
xy-0789xy-Axyxy Insulin Protein /APC荧光素APC标记猪胰岛素蛋白
xy-xy0002-Axyxy KLH/APC荧光素APC标记血蓝蛋白
xy-0945xy-Axyxy HSA(Human sermu albumin)/APC荧光素APC标记人血白蛋白
xy-2179xy-Axyxy AACT/APC荧光素APC标记胰糜蛋白酶
xy-0437xy-xyy3 Streptavidin/Cy3荧光素Cy3标记链霉亲和素
xy-0312xy-xyy3 Avidin/Cy3荧光素Cy3标记亲合素
xy-0362xy-xyy3 Protein A/Cy3Cy3标记蛋白A
xy-0295xy-xyy3 Rabbit IgG/Cy3荧光素Cy3标记兔IgG(细胞流式同型对照)
xy-0296xy-xyy3 Mouse IgG/Cy3荧光素Cy3标记小鼠IgG(细胞流式同型对照)
xy-0294xy-xyy3 Goat IgG/Cy3荧光素Cy3标记羊IgG(细胞流式同型对照)
xy-0293xy-xyy3 Rat IgG/Cy3荧光素Cy3标记大鼠IgG(细胞流式同型对照)
xy-0326xy-xyy3 Bovine IgG/Cy3荧光素Cy3标记牛IgG
xy-0327xy-xyy3 Bovine IgM/Cy3荧光素Cy3标记牛IgM
xy-0310xy-xyy3 Chicken IgG/Cy3荧光素Cy3标记鸡IgG