BioLegend 942202 Purified anti

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BioLegend 942202 Purified anti-Acetyl-CoA Carboxylase 1
产品简介：
产品品牌：BioLegend
产品货号：942202
产品名称：BioLegend 942202 Purified anti-Acetyl-CoA Carboxylase 1
产品规格： 100 µg

产品说明：
Clone   W19216A (See other available formats)
Regulatory Status   RUO
Other Names
Acetyl-CoA Carboxylase Alpha, Acetyl-Coenzyme A Carboxylase Alpha, ACC1, ACCA
Isotype   Rat IgG2a, κ

描述
乙酰辅酶a羧化酶（ACC）是一种胞浆酶，催化乙酰辅酶a羧基化为丙二酰辅酶a，这是脂肪酸生物合成的起始和限速步骤。ACC存在两种表现出组织特异性分布的亚型。ACC1主要在脂肪生成组织中表达，而ACC2在氧化组织中发现。作为对细胞ATP耗竭的反应，AMPK在Ser79磷酸化ACC1，导致酶活性损失。ACC1是各种代谢性疾病的临床靶点，也有助于肿瘤细胞的代谢重编程。
Acetyl-CoA carboxylase (ACC) is a cytosolic enzyme that catalyzes carboxylation of acetyl-CoA to malonyl-CoA, the initiating and rate-limiting step in fatty acid biosynthesis. Two isoforms of ACC exist that show tissue-specific distribution. ACC1 is predominantly expressed in lipogenic tissues, while ACC2 is found in oxidative tissues. In response to depletion of cellular ATP, AMPK phosphorylates ACC1 at Ser79, resulting in loss of enzymatic activity. ACC1 is a clinical target for various metabolic diseases, and also contributes to metabolic reprogramming in tumor cells.

Product Details
Isotype Control   Purified Rat IgG2a, κ Isotype Ctrl
Verified Reactivity   Human
Antibody Type    Monoclonal
Host Species   Rat
Immunogen
Partial recombinant human acetyl-CoA carboxylase 1 protein

Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide

Preparation
The antibody was purified by affinity chromatography.
Concentration    0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application   WB - Quality tested
ICC, IP - Verified

Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 1.0 µg/mL. For immunocytochemistry, a concentration range of 1.0 - 2.0 μg/mL is recommended. For immunoprecipitation, the suggested use of this reagent is 2.5 µg/test. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure
Acetyl-CoA carboxylase 1 is a 2,346 amino acid protein with a predicted molecular weight of 266 kD.
Distribution   Lipogenic tissue/Cytosol
Function    Fatty acid biosynthesis
Biology Area    Cell Biology, Mitochondrial Function
Molecular Family    Enzymes and Regulators

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