BioLegend 137206 PE anti-mouse

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BioLegend 137206 PE anti-mouse/human Helios
产品简介：
产品品牌：BioLegend
产品货号：137206
产品名称：BioLegend 137206 PE anti-mouse/human Helios
产品规格：25 tests

产品说明：
Clone  22F6 (See other available formats)
Regulatory Status  RUO
Other Names  IKZF2, IKAROS family zinc finger 2, ANF1A2, ZNF1A2, ZNFN1A2
Isotype  Armenian Hamster IgG

描述
Helios是锌指转录因子Ikaros家族的一员。它包含一个由2个锌指结构域组成的C末端区域，该结构域介导家族成员之间的二聚化。Helios最初是从小鼠胸腺瘤系中克隆出来的。它主要在外周T细胞和胸腺细胞中表达。在调节性T细胞亚群中发现了高水平的它。太阳神在T细胞的发育和稳态中起着重要作用。Helios的过度表达深刻地改变了αβT细胞的分化和活化。已经确定，Helios在B细胞中的沉默对于维持正常的B细胞功能至关重要。太阳神也参与肿瘤免疫。
Helios is a member of the Ikaros family of zinc finger transcription factors.  It contains a C-terminal region composed of 2 zinc-finger domains that mediate dimerization between the family members.  Helios was originally cloned from a mouse thymoma line. It is mainly expressed in peripheral T cells and thymocytes.  It is found at high levels in a subpopulation of regulatory T cells.  Helios plays an important role in T cell development and homeostasis.  Overexpression of Helios profoundly alters αβ T cell differentiation and activation.  It has been determined that silencing of Helios in B cells is critical for maintaining normal B cell function.  Helios is also involved in tumor immunity.

Product Details
Isotype Control  PE Armenian Hamster IgG Isotype Ctrl
Verified Reactivity  Mouse, Human
Antibody Type  Monoclonal
Host Species  Armenian Hamster
Immunogen  Helios peptide (aa 51-107)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  ICFC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Nuclear™ Transcription Factor Staining Protocol. It is recommended that the reagent be titrated for optimal performance for each application.
For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser  Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Antigen Details
Structure
A zinc finger nuclear transcription factor of the Ikaros family, containing 2 zinc-finger domains in C-terminal region.
Distribution
Regulatory T cells (Tregs), conventional T cells, thymocytes.
Function
Plays an important role in T cell development and homeostasis, involved in tumor immunity.
Cell Type  T cells, Thymocytes, Tregs

Biology Area
Cell Biology, Immunology, Transcription Factors
Molecular Family  Nuclear Markers

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