BioLegend 443707 LEGEND MAX™ M

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BioLegend 443707 LEGEND MAX™ Mouse NGAL (Lipocalin-2) ELISA Kit
产品简介：
产品品牌：BioLegend
产品货号：443707
产品名称：BioLegend 443707 LEGEND MAX™ Mouse NGAL (Lipocalin-2) ELISA Kit
产品规格：1 Pre-coated Plate

产品说明：
Regulatory Status   RUO
Other Names
Lipocalin-2, Siderocalin, 24p3, Uterocalin, Neu-related lipocalin

描述
中性粒细胞明胶酶相关脂钙蛋白（NGAL），也称为脂钙蛋白-2，铁钙素，24p3，子宫钙素或中性钙蛋白，是脂质卡林家族的成员。它是一种分泌蛋白（25kD），可捕获以高亲和力结合铁的细菌铁载体。对人类样本的研究表明，NGAL主要以单体形式存在，一小部分以同源二聚体和同源三聚体形式存在。它还可以与MMP-9形成异二聚体，与MMP-9和TIMP-1形成异源三聚体。小鼠NGAL分别与人和大鼠共享62%和80%的氨基酸序列同一性。
NGAL的功能多种多样，并继续研究。NGAL 通过铁载体介导的铁耗竭作为有效的抗菌剂。NGAL敲除小鼠表现出对抗细菌感染的能力下降。NGAL 已被用作急性和慢性肾损伤的早期预测和预后生物标志物。它与乳腺癌、肺癌、结肠癌和胰腺癌有关，在肿瘤发展过程中具有多种上下文依赖性影响。这可能涉及细胞生长、存活、迁移、侵袭和血管生成。当NGAL与MMP-9形成复合物时，它可以保护MMP-9免受降解，从而保留MMP-9的酶活性，该活性参与了几种癌症的发展。
LEGEND MAX™小鼠NGAL ELISA试剂盒是一种夹心酶联免疫吸附测定（ELISA），带有96孔试纸板，预包被大鼠单克隆抗小鼠NGAL抗体。检测抗体是一种生物素化大鼠单克隆抗小鼠NGAL抗体。该试剂盒专为准确定量来自细胞培养上清液、细胞裂解物、血清、血浆、尿液和其他生物体液的小鼠 NGAL 而设计。该试剂盒使用即用型试剂进行了分析验证。
Neutrophil Gelatinase-Associated Lipocalin (NGAL), also known as Lipocalin-2, Siderocalin, 24p3, Uterocalin, or Neu-related Lipocalin, is a member of the lipocalin family. It is a secreted protein (25kD), which captures bacterial siderophores that bind iron with high affinity. Studies with human samples show that NGAL predominantly exists in monomeric form, with a small portion in homodimeric and homotrimeric forms. It can also form a heterodimer with MMP-9 and a heterotrimer with MMP-9 and TIMP-1. Mouse NGAL shares 62% and 80% amino acid sequence identity with human and rat, respectively.

The functions of NGAL are diverse and continue to be studied. NGAL acts as a potent anti-bacterial agent via siderophore-mediated iron depletion. NGAL knockout mice exhibit decreased ability to combat bacterial infection. NGAL has been used as an early predictive and prognostic biomarker for acute and chronic kidney injuries. It has been associated with breast, lung, colon, and pancreatic cancer, having diverse, context-dependent effects during tumor development. This may involve cell growth, survival, migration, invasion, and angiogenesis. When NGAL forms a complex with MMP-9, it protects MMP-9 from degradation, thereby preserving MMP-9’s enzymatic activity, which has been involved in the development of several types of cancers.

The LEGEND MAX™ Mouse NGAL ELISA kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with rat monoclonal anti-mouse NGAL antibody. The Detection Antibody is a biotinylated rat monoclonal anti-mouse NGAL antibody. This kit is specifically designed for the accurate quantitation of mouse NGAL from cell culture supernatant, cell lysate, serum, plasma, urine, and other biological fluids. This kit is analytically validated with ready-to-use reagents.

Product Details
Verified Reactivity   Mouse
Application   ELISA

Antigen Details
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity, Signal Transduction

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