BioLegend 130907 PE anti-mouse CD339 (Jagged 1) 产品简介: 产品品牌:BioLegend 产品货号:130907 产品名称:BioLegend 130907 PE anti-mouse CD339 (Jagged 1) 产品规格:25 µg
产品说明: Clone HMJ1-29 (See other available formats) Regulatory Status RUO Other Names JAG1, Jagged1 Isotype Armenian Hamster IgG
描述 CD339,也称为Jagged 1,是一种135kD的1型跨膜蛋白,具有一个DSL(Delta、Serrate、LagZ)结构域、15个EGF样结构域和一个富含半胱氨酸的区域。Jagged 1由多种细胞类型表达,包括巨噬细胞、树突状细胞亚群、星形胶质细胞、基质细胞和上皮细胞。CD339调节各种组织中的细胞命运决定,并在心血管系统的神经发生和发育中发挥重要作用。研究表明,Jagged 1参与Th2极化和Treg诱导。 CD339, also known as Jagged 1, is a 135 kD type 1 transmembrane protein, with one DSL (Delta, Serrate, LagZ) domain, fifteen EGF-like domains, and one cysteine-rich region. Jagged 1 is expressed by many cell types including macrophages, subsets of dendritic cells, astrocytes, stromal, and epithelial cells. CD339 regulates cell fate decisions in various tissues, and has an important role in neurogenesis and development of the cardiovascular system. Studies suggest Jagged 1 is involved in Th2 polarization and Treg induction.
Product Details Isotype Control PE Armenian Hamster IgG Isotype Ctrl Verified Reactivity Mouse Antibody Type Monoclonal Host Species Armenian Hamster Immunogen Murine Jagged 1-Fc fusion protein Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Preparation The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. Concentration 0.2 mg/ml Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested
Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. Excitation Laser Blue Laser (488 nm) Green Laser (532 nm)/Yellow-Green Laser (561 nm) Application Notes Additional reported applications (for the relevant formats) include: in vivo blocking of Jagged 1 in EAE1 and immunohistochemical staining of frozen spleen sections2
Antigen Details Structure Type 1 transmembrane protein, 1 DSL (Delta, Serrate, LagZ) domain, 15 EGF-like domains, 1 cystein riche region; 135 kD Distribution Macrophages, subsets of dendritic cells, stromal cells, epithelial cells, astrocytes Function Regulates cell fate decisions in various tissues, important role in cardiovascular system development, neurogenesis, and T cell polarization to Th2 lineage Ligand/Receptor Notch1, Notch2, Notch3 Cell Type Astrocytes, Dendritic cells, Epithelial cells, Macrophages Biology Area Angiogenesis, Cell Biology, Immunology Molecular Family CD Molecules
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