BioLegend 442707 LEGEND MAX™ M

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BioLegend 442707 LEGEND MAX™ Mouse Erythropoietin (EPO) ELISA Kit
产品简介：
产品品牌：BioLegend
产品货号：442707
产品名称：BioLegend 442707 LEGEND MAX™ Mouse Erythropoietin (EPO) ELISA Kit
产品规格：1 Pre-coated Plate

产品说明：
Regulatory Status  RUO
Other Names  Hematopoietin

描述
促红细胞生成素（EPO）是调节红细胞生成最重要的激素。它是一种糖蛋白，也称为造血素。EPO主要由肾脏和肝脏响应缺氧产生，诱导红细胞生成。小鼠EPO是一种由166个氨基酸组成的分泌蛋白，预测分子量为~18.6 kD。然而，由于糖基化严重，它在SDS-PAGE上以~33-48 kD迁移。EPO与血小板生成素（TPO）密切相关，并且在物种间高度保守，小鼠EPO分别与大鼠和人类相同95%和80%。

EPO通过与红系前体上的受体EPO R（一种同源二聚体）结合来发挥作用，并促进其分化和成熟。正如预期的那样，血清 EPO 水平升高是响应导致组织缺氧的各种疾病（例如失血、高海拔、心脏或肺部疾病以及贫血）。EPO水平升高也可能是由于肝脏和肾脏癌细胞的产生增加。EPO水平降低常见于慢性肾功能衰竭和其他导致贫血的慢性疾病。小鼠内源性EPO和重组EPO共享相同的氨基酸序列，但糖基化谱不同。

LEGEND MAX™小鼠EPO ELISA试剂盒是一种夹心酶联免疫吸附测定（ELISA），带有预包被大鼠单克隆抗小鼠EPO抗体的96孔试板。检测抗体是一种生物素化的多克隆山羊抗小鼠EPO抗体。该试剂盒专为准确定量来自细胞培养上清液、血清、血浆（肝素）、组织匀浆和其他生物体液的小鼠EPO而设计。该试剂盒使用即用型试剂进行了分析验证。

Erythropoietin (EPO) is the most important hormone regulating erythropoiesis. It is a glycoprotein also known as hematopoietin. EPO is mainly produced by kidney and liver in response to hypoxia to induce red blood cell production. Mouse EPO is a secreted protein of 166 amino acids with a predicted molecular mass of ~18.6 kD. However, it migrates on SDS-PAGE at ~33-48 kD due to heavy glycosylation. EPO is closely related to thrombopoietin (TPO) and highly conserved across species, with mouse EPO being 95% and 80% identical to rat and human, respectively.

EPO functions through binding to its receptor, EPO R, a homodimer, on erythoid precursors, and promotes their differentiation and maturation. As expected, serum levels of EPO are elevated in response to various conditions that result in tissue hypoxia (e.g., blood loss, high altitude, cardiac or pulmonary disease, and anemia). Increased EPO levels can also be due to increased production by cancer cells of the liver and kidney. Decreased levels of EPO are often seen with chronic renal failure and other chronic diseases, which causes anemia. Mouse endogenous EPO and recombinant EPO share the same amino acid sequence, with differences in the glycosylation profiles.

The LEGEND MAX™ Mouse EPO ELISA kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with a rat monoclonal anti-mouse EPO antibody. The Detection Antibody is a biotinylated polyclonal goat anti-mouse EPO antibody. This kit is specifically designed for the accurate quantitation of mouse EPO from cell culture supernatant, serum, plasma (heparin), tissue homogenates and other biological fluids. This kit is analytically validated with ready-to-use reagents.

Product Details
Verified Reactivity   Mouse
Application   ELISA

Antigen Details
Biology Area    Cell Biology, Signal Transduction
Molecular Family   Cytokines/Chemokines, Growth Factors

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