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99
- 英文名：
Alexa Fluor® 488 anti-mouse/rat/human FOXP3
- 供应商：
北京云肽生物科技有限公司
BioLegend 320012 Alexa Fluor® 488 anti-mouse/rat/human FOXP3
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
BioLegend 公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 320012 Alexa Fluor® 488 anti-mouse/rat/human FOXP3
产品简介：
产品品牌：BioLegend
产品货号：320012
产品名称：BioLegend 320012 Alexa Fluor® 488 anti-mouse/rat/human FOXP3
产品规格：100 tests
产品说明：
Clone 150D (See other available formats)
Regulatory Status RUO
Other Names
Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2
Isotype Mouse IgG1, κ
描述
FOXP3是一种50-55 kD转录因子，也称为叉头盒蛋白P3，Scurfin，JM2或IPEX。它被认为是T调节细胞的主调控基因和比大多数细胞表面标志物（如CD4和CD25）更具特异性的标志物。FOXP3 在 CD4+/CD25- 细胞中的转导表达已被证明可诱导 GITR、CD103 和 CTLA4 并赋予 T 调节细胞表型。FOXP3在人类和“scurfy”小鼠的X连锁自身免疫过敏性失调综合征（XLAAD或IPEX）中发生突变。FOXP3的过表达已被证明会导致免疫状态低下，这表明该转录因子是T细胞活性的中枢调节因子。在人类中，与小鼠不同，已经报道了FOXP3的两种亚型：一种（FOXP3）对应于规范的全长序列;另一个（FOXP3 δ2）缺乏外显子2。150D单克隆抗体与人，小鼠和大鼠FOXP3反应。150D抗体可识别由外显子2编码的FOXP3表位。
FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2.
Product Details
Isotype Control
Alexa Fluor® 488 Mouse IgG1, κ Isotype Ctrl (ICFC)
Verified Reactivity Human, Mouse, Rat
Reported Reactivity Cynomolgus, Rhesus, Baboon
Antibody Type Monoclonal
Host Species Mouse
Immunogen Full-length FOXP3 protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The FOXP3 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application ICFC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Nuclear™ Transcription Factor Staining Protocol. For flow cytometric staining, the suggested use of this reagent is 5 µl per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses
Excitation Laser Blue Laser (488 nm)
Application Notes
NOTE:
For flow cytometric staining with this clone, True-Nuclear™ Transcription Factor Buffer Set (Cat. No. 424401) offers improved staining and is highly recommended.
Antigen Details
Structure
Forkhead/winged-helix transcription factor family, approximately 50 kD, contains zinc finger and forkhead domains
Distribution Nuclear; expressed in T regulatory cells
Function
Transcription factor proposed to be a master regulatory gene in T regulatory cell development and a critical factor for immune homeostasis
Interaction Interacts with DNA
Cell Type Tregs
Biology Area
Cell Biology, Immunology, Transcription Factors
Molecular Family Nuclear Markers
以下是 BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
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BioLegend 156523 PE/Cyanine5 anti-mouse NK-1.1 S17016D 25 ug
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BioLegend 156610 PE/Cyanine7 anti-mouse CD16/32 S17011E 100 ug
BioLegend 156613 FITC anti-mouse CD16/32 S17011E 25 ug
BioLegend 156614 FITC anti-mouse CD16/32 S17011E 100 ug
BioLegend 156621 APC/Fire™ 750 anti-mouse CD16/32 S17011E 25 ug
BioLegend 156703 PE anti-mouse CD163 S15049F 25 ug
BioLegend 156704 PE anti-mouse CD163 S15049F 100 ug
BioLegend 156707 PE/Cyanine7 anti-mouse CD163 S15049F 25 ug
BioLegend 156804 Alexa Fluor® 647 anti-mouse CLEC4F 3E3F9 100 ug
BioLegend 156904 PE anti-mouse CD103 Recombinant QA17A24 100 ug
BioLegend 156911 FITC anti-mouse CD103 Recombinant QA17A24 25 ug
BioLegend 156912 FITC anti-mouse CD103 Recombinant QA17A24 100 ug
BioLegend 157004 PE anti-mouse CD154 (CD40L) SA047C3 100 ug
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
BioLegend 公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 320012 Alexa Fluor® 488 anti-mouse/rat/human FOXP3
产品简介：
产品品牌：BioLegend
产品货号：320012
产品名称：BioLegend 320012 Alexa Fluor® 488 anti-mouse/rat/human FOXP3
产品规格：100 tests
产品说明：
Clone 150D (See other available formats)
Regulatory Status RUO
Other Names
Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2
Isotype Mouse IgG1, κ
描述
FOXP3是一种50-55 kD转录因子，也称为叉头盒蛋白P3，Scurfin，JM2或IPEX。它被认为是T调节细胞的主调控基因和比大多数细胞表面标志物（如CD4和CD25）更具特异性的标志物。FOXP3 在 CD4+/CD25- 细胞中的转导表达已被证明可诱导 GITR、CD103 和 CTLA4 并赋予 T 调节细胞表型。FOXP3在人类和“scurfy”小鼠的X连锁自身免疫过敏性失调综合征（XLAAD或IPEX）中发生突变。FOXP3的过表达已被证明会导致免疫状态低下，这表明该转录因子是T细胞活性的中枢调节因子。在人类中，与小鼠不同，已经报道了FOXP3的两种亚型：一种（FOXP3）对应于规范的全长序列;另一个（FOXP3 δ2）缺乏外显子2。150D单克隆抗体与人，小鼠和大鼠FOXP3反应。150D抗体可识别由外显子2编码的FOXP3表位。
FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2.
Product Details
Isotype Control
Alexa Fluor® 488 Mouse IgG1, κ Isotype Ctrl (ICFC)
Verified Reactivity Human, Mouse, Rat
Reported Reactivity Cynomolgus, Rhesus, Baboon
Antibody Type Monoclonal
Host Species Mouse
Immunogen Full-length FOXP3 protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The FOXP3 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application ICFC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Nuclear™ Transcription Factor Staining Protocol. For flow cytometric staining, the suggested use of this reagent is 5 µl per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses
Excitation Laser Blue Laser (488 nm)
Application Notes
NOTE:
For flow cytometric staining with this clone, True-Nuclear™ Transcription Factor Buffer Set (Cat. No. 424401) offers improved staining and is highly recommended.
Antigen Details
Structure
Forkhead/winged-helix transcription factor family, approximately 50 kD, contains zinc finger and forkhead domains
Distribution Nuclear; expressed in T regulatory cells
Function
Transcription factor proposed to be a master regulatory gene in T regulatory cell development and a critical factor for immune homeostasis
Interaction Interacts with DNA
Cell Type Tregs
Biology Area
Cell Biology, Immunology, Transcription Factors
Molecular Family Nuclear Markers
以下是 BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
BioLegend 156504 PE anti-mouse NK-1.1 S17016D 100 ug
BioLegend 156505 APC anti-mouse NK-1.1 S17016D 25 ug
BioLegend 156506 APC anti-mouse NK-1.1 S17016D 100 ug
BioLegend 156507 FITC anti-mouse NK-1.1 S17016D 25 ug
BioLegend 156508 FITC anti-mouse NK-1.1 S17016D 100 ug
BioLegend 156519 APC/Fire™ 810 anti-mouse NK-1.1 S17016D 25 ug
BioLegend 156521 KIRAVIA Blue 520™ anti-mouse NK-1.1 S17016D 25 ug
BioLegend 156523 PE/Cyanine5 anti-mouse NK-1.1 S17016D 25 ug
BioLegend 156525 PerCP/Cyanine5.5 anti-mouse NK-1.1 S17016D 25 ug
BioLegend 156603 TruStain FcX™ PLUS (anti-mouse CD16/32) S17011E 50 ug
BioLegend 156610 PE/Cyanine7 anti-mouse CD16/32 S17011E 100 ug
BioLegend 156613 FITC anti-mouse CD16/32 S17011E 25 ug
BioLegend 156614 FITC anti-mouse CD16/32 S17011E 100 ug
BioLegend 156621 APC/Fire™ 750 anti-mouse CD16/32 S17011E 25 ug
BioLegend 156703 PE anti-mouse CD163 S15049F 25 ug
BioLegend 156704 PE anti-mouse CD163 S15049F 100 ug
BioLegend 156707 PE/Cyanine7 anti-mouse CD163 S15049F 25 ug
BioLegend 156804 Alexa Fluor® 647 anti-mouse CLEC4F 3E3F9 100 ug
BioLegend 156904 PE anti-mouse CD103 Recombinant QA17A24 100 ug
BioLegend 156911 FITC anti-mouse CD103 Recombinant QA17A24 25 ug
BioLegend 156912 FITC anti-mouse CD103 Recombinant QA17A24 100 ug
BioLegend 157004 PE anti-mouse CD154 (CD40L) SA047C3 100 ug
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BioLegend 320012 Alexa Fluor® 488 anti-mouse/rat/human FOXP3
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